New hope for liver cancer: Triple-Drug cocktail enters Mid-Stage trial

NCT ID NCT06880523

Recruiting now Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 5 times

Summary

This phase 2 trial tests whether adding lenvatinib to the STRIDE regimen (durvalumab plus tremelimumab) works better than STRIDE alone for people with advanced liver cancer that cannot be surgically removed. About 140 adults who have not had prior systemic therapy will be enrolled. The study compares progression-free survival and overall survival between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: durvalumab, tremelimumab, and lenvatinib
What this could lead to: If successful, this could lead to a more effective combination therapy for people with advanced liver cancer that cannot be removed by surgery.
What could go wrong: This is a mid-stage trial with only 140 participants, so results may not apply to everyone. Adding lenvatinib may increase side effects without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA

Contacts and locations

Locations

Arthur J.E. Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
BCCA - Kelowna
RECRUITING

Kelowna, British Columbia, V1Y 5L3, Canada
BCCA - Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
CHUM-Centre Hospitalier de l'Universite de Montreal
RECRUITING

Montreal, Quebec, H2X 3E4, Canada
Juravinski Cancer Centre at Hamilton Health Sciences
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Kingston Health Sciences Centre
RECRUITING

Kingston, Ontario, K7L 2V7, Canada
London Health Sciences Centre Research Inc.
RECRUITING

London, Ontario, N6A 5W9, Canada
Ottawa Hospital Research Institute
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Saskatoon Cancer Centre
RECRUITING

Saskatoon, Saskatchewan, S7N 4H4, Canada
The Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Trillium Health Partners - Credit Valley Hospital
RECRUITING

Mississauga, Ontario, L5M 2N1, Canada
University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Waterloo Regional Health Network (WRHN)
RECRUITING

Kitchener, Ontario, N2G 1G3, Canada

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