New radiation technique may ease cancer bone pain better than standard therapy

NCT ID NCT06391242

Recruiting now Symptom relief Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 12, 2026 · Updated 5 times

Summary

This phase 3 trial tests whether a precise, high-dose radiation technique (SBRT) provides better pain relief than standard radiation for cancer patients with painful bone metastases not in the spine. About 230 adults with solid tumors and moderate to severe pain will be randomly assigned to one of the two treatments. The main goal is to see if SBRT leads to complete pain relief more often than standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (stereotactic body radiotherapy or conventional palliative radiotherapy)
What this could lead to: If SBRT works better, it could offer more effective pain relief for people with cancer that has spread to bones, with fewer side effects on healthy tissue.
What could go wrong: This is a late-stage trial, but SBRT is more complex and may not prove superior to standard treatment. There is a risk of bone fracture or need for repeat treatment.

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Conditions

The condition(s) this trial relates to.

metastatic carcinoma in the bone metastatic malignant neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER METASTATIC

Contacts and locations

Locations

Arthur J.E. Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
BCCA - Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
CHUM-Centre Hospitalier de l'Universite de Montreal
RECRUITING

Montreal, Quebec, H2X 3E4, Canada
CIUSSS de l'Est-de-I'lle-de-Montreal
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Hotel-Dieu de Quebec
RECRUITING

Québec, Quebec, G1R 2J6, Canada
Juravinski Cancer Centre at Hamilton Health Sciences
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Kingston Health Sciences Centre
RECRUITING

Kingston, Ontario, K7L 2V7, Canada
London Health Sciences Centre Research Inc.
RECRUITING

London, Ontario, N6A 5W9, Canada
Odette Cancer Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Stronach Regional Health Centre at Southlake
RECRUITING

Newmarket, Ontario, L3Y 2P9, Canada
University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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