Brain cancer trial tests if precision radiation can beat whole brain therapy for memory preservation

NCT ID NCT03550391

Recruiting now Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase III trial is for people with 5 to 15 brain metastases from cancers that are not blood cancers. It compares two treatments: stereotactic radiosurgery (SRS), which delivers high-dose radiation to small spots in one or two days, versus whole brain radiation that avoids the memory center (hippocampus) plus a drug called memantine to protect memory. The study aims to see which approach better extends life and preserves thinking skills. About 206 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Memantine (a drug to protect memory) and radiation therapy (SRS or HA-WBRT)
What this could lead to: If this trial succeeds, it could show that targeted radiosurgery alone is as good as or better than whole brain radiation plus a memory-protecting drug for controlling brain metastases while preserving cognitive function.
What could go wrong: This is a phase III trial, but results may not apply to all patients. The treatments have risks like radiation side effects, and memantine may not prevent all memory problems. The trial is still recruiting, so outcomes are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Arthur J E Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada

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AtlantiCare Surgery Center
RECRUITING

Egg Harbor, New Jersey, 08234, United States

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BCCA-Vancouver Cancer Centre
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada

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Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

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Billings Clinic Cancer Center
SUSPENDED

Billings, Montana, 59101, United States
Boca Raton Regional Hospital
ACTIVE_NOT_RECRUITING

Boca Raton, Florida, 33486, United States
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
RECRUITING

Québec, Quebec, G1R 2J6, Canada

Contact

Contact Email: •••••@•••••
CHUM - Centre Hospitalier de l'Universite de Montreal
RECRUITING

Montreal, Quebec, H2X 3E4, Canada

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Contact Phone: •••-•••-•••• Email: •••••@•••••
CSSS Champlain-Charles Le Moyne
SUSPENDED

Greenfield Park, Quebec, J4V 2H1, Canada
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
SUSPENDED

Sherbrooke, Quebec, J1H 5N4, Canada
City of Hope Antelope Valley
RECRUITING

Lancaster, California, 93534, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

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City of Hope Corona
RECRUITING

Corona, California, 92882, United States

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City of Hope South Bay
RECRUITING

Torrance, California, 90503, United States

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City of Hope South Pasadena
RECRUITING

South Pasadena, California, 91030, United States

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City of Hope Upland
RECRUITING

Upland, California, 91786, United States

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City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States

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Community Cancer Center North
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46256, United States
Cone Health Cancer Center
RECRUITING

Greensboro, North Carolina, 27403, United States

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Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada

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Dartmouth Cancer Center - North
ACTIVE_NOT_RECRUITING

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
ACTIVE_NOT_RECRUITING

Lebanon, New Hampshire, 03756, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States

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East Carolina University
ACTIVE_NOT_RECRUITING

Greenville, North Carolina, 27834, United States
Emory Saint Joseph's Hospital
SUSPENDED

Atlanta, Georgia, 30342, United States
Emory University Hospital/Winship Cancer Institute
SUSPENDED

Atlanta, Georgia, 30322, United States
Fox Chase Cancer Center
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fox Chase Cancer Center Buckingham
ACTIVE_NOT_RECRUITING

Furlong, Pennsylvania, 18925, United States
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

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Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

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HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States

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Huntsman Cancer Institute/University of Utah
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84112, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States

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Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada

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Contact
Juravinski Cancer Centre at Hamilton Health Sciences
ACTIVE_NOT_RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Kaiser Permanente Cancer Treatment Center
ACTIVE_NOT_RECRUITING

South San Francisco, California, 94080, United States
Kaiser Permanente Medical Center - Santa Clara
ACTIVE_NOT_RECRUITING

Santa Clara, California, 95051, United States
Kaiser Permanente-Rancho Cordova Cancer Center
ACTIVE_NOT_RECRUITING

Rancho Cordova, California, 95670, United States
Legacy Good Samaritan Hospital and Medical Center
RECRUITING

Portland, Oregon, 97210, United States

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London Regional Cancer Program
RECRUITING

London, Ontario, N6A 4L6, Canada

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Loyola University Medical Center
SUSPENDED

Maywood, Illinois, 60153, United States
Luminis Health Anne Arundel Medical Center
ACTIVE_NOT_RECRUITING

Annapolis, Maryland, 21401, United States
Mayo Clinic in Florida
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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Memorial Hospital West
ACTIVE_NOT_RECRUITING

Pembroke Pines, Florida, 33028, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
ACTIVE_NOT_RECRUITING

Hollywood, Florida, 33021, United States
Methodist Medical Center of Illinois
RECRUITING

Peoria, Illinois, 61636, United States

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Mission Hospital
ACTIVE_NOT_RECRUITING

Asheville, North Carolina, 28801, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States

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Moffitt Cancer Center
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33612, United States
Northwestern Medicine Cancer Center Warrenville
ACTIVE_NOT_RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern University
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
OSF Saint Francis Medical Center
RECRUITING

Peoria, Illinois, 61637, United States

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Piedmont Hospital
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30309, United States
QEII Health Sciences Centre/Nova Scotia Health Authority
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada

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Regions Hospital
SUSPENDED

Saint Paul, Minnesota, 55101, United States
Rohnert Park Cancer Center
ACTIVE_NOT_RECRUITING

Rohnert Park, California, 94928, United States
SUNY Upstate Medical Center-Community Campus
SUSPENDED

Syracuse, New York, 13215, United States
Saint Alphonsus Cancer Care Center-Boise
SUSPENDED

Boise, Idaho, 83706, United States
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States

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Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

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Self Regional Healthcare
ACTIVE_NOT_RECRUITING

Greenwood, South Carolina, 29646, United States
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

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Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

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Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

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South Sacramento Cancer Center
ACTIVE_NOT_RECRUITING

Sacramento, California, 95823, United States
State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States

Contact

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The Permanente Medical Group-Roseville Radiation Oncology
ACTIVE_NOT_RECRUITING

Roseville, California, 95678, United States
The Research Institute of the McGill University Health Centre (MUHC)
SUSPENDED

Montreal, Quebec, H3H 2R9, Canada
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States

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UC Irvine Health/Chao Family Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Orange, California, 92868, United States
UC San Diego Moores Cancer Center
SUSPENDED

La Jolla, California, 92093, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States

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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States

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UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States

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University Health Network-Princess Margaret Hospital
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States

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University of Arizona Cancer Center-Orange Grove Campus
RECRUITING

Tucson, Arizona, 85704, United States

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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States

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University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States

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University of Oklahoma Health Sciences Center
ACTIVE_NOT_RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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Walter Reed National Military Medical Center
RECRUITING

Bethesda, Maryland, 20889-5600, United States

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Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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