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Could less be more? major trial tests shorter drug regimen for myeloma

NCT ID NCT06182774

Recruiting now Disease control Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study is for older adults with newly diagnosed multiple myeloma who cannot have a stem cell transplant. It compares taking the drugs daratumumab or isatuximab continuously versus stopping after about a year and a half, while continuing other medications. The goal is to see if the shorter treatment works just as well to control the disease and has fewer side effects. About 570 participants will be enrolled.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

  • Algoma District Cancer Program

    RECRUITING

    Sault Ste. Marie, Ontario, P6B 0A8, Canada

  • Allan Blair Cancer Centre

    RECRUITING

    Regina, Saskatchewan, S4T 7T1, Canada

  • BCCA - Kelowna

    RECRUITING

    Kelowna, British Columbia, V1Y 5L3, Canada

  • BCCA - Vancouver

    RECRUITING

    Vancouver, British Columbia, V5Z 4E6, Canada

  • CHU de Quebec-Hopital l'Enfant-Jesus (HEJ)

    RECRUITING

    Québec, Quebec, G1J 1Z4, Canada

  • CIUSSS de l'Est-de-I'lle-de-Montreal

    RECRUITING

    Montreal, Quebec, H1T 2M4, Canada

  • CancerCare Manitoba

    RECRUITING

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Cross Cancer Institute

    RECRUITING

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dr. H. Bliss Murphy Cancer Centre

    RECRUITING

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

  • Juravinski Cancer Centre at Hamilton Health Sciences

    RECRUITING

    Hamilton, Ontario, L8V 5C2, Canada

  • Kingston Health Sciences Centre

    RECRUITING

    Kingston, Ontario, K7L 2V7, Canada

  • Lakeridge Health Oshawa

    RECRUITING

    Oshawa, Ontario, L1G 2B9, Canada

  • London Health Sciences Centre Research Inc.

    RECRUITING

    London, Ontario, N6A 5W9, Canada

  • Niagara Health System

    RECRUITING

    St. Catharines, Ontario, L2S 0A9, Canada

  • Ottawa Hospital Research Institute

    RECRUITING

    Ottawa, Ontario, K1H 8L6, Canada

  • Regional Health Authority B, Zone 2

    RECRUITING

    Saint John, New Brunswick, E2L 4L2, Canada

  • Royal Victoria Regional Health Centre

    RECRUITING

    Barrie, Ontario, L4M 6M2, Canada

  • Saskatoon Cancer Centre

    RECRUITING

    Saskatoon, Saskatchewan, S7N 4H4, Canada

  • St. Joseph's Health Centre

    RECRUITING

    Toronto, Ontario, M6R 1B5, Canada

  • St. Mary's Hospital

    RECRUITING

    Montreal, Quebec, H3T 1M5, Canada

  • St. Michael's Hospital

    RECRUITING

    Toronto, Ontario, M5B 1W8, Canada

  • Stronach Regional Health Centre at Southlake

    RECRUITING

    Newmarket, Ontario, L3Y 2P9, Canada

  • The Jewish General Hospital

    RECRUITING

    Montreal, Quebec, H3T 1E2, Canada

  • The Moncton Hospital

    RECRUITING

    Moncton, New Brunswick, E1C 6Z8, Canada

  • The Research Institute of the McGill University

    RECRUITING

    Montreal, Quebec, H4A 3J1, Canada

  • Waterloo Regional Health Network (WRHN)

    RECRUITING

    Kitchener, Ontario, N2G 1G3, Canada

  • William Osler Health System

    RECRUITING

    Brampton, Ontario, L6R 3J7, Canada

  • Windsor Regional Cancer Centre

    RECRUITING

    Windsor, Ontario, N8W 2X3, Canada

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