New hope for throat cancer patients: smarter treatments on the horizon

NCT ID NCT04116047

Ongoing Disease control Sponsor: University of Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether different drug combinations can improve survival and reduce side effects for people with intermediate or high-risk oropharyngeal (throat) cancer. About 785 participants will receive one of several experimental treatments alongside standard chemoradiotherapy. The goal is to find a regimen that works better than current options.

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Conditions

The condition(s) this trial relates to.

oropharyngeal carcinoma oropharynx cancer oropharynx squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OROPHARYNGEAL CANCER

Contacts and locations

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Locations

Aberdeen Royal Infirmary

Aberdeen, Aberdeen, AB25 2ZN, United Kingdom
Addenbrooke's Hospital

Cambridge, CB2 0QQ, United Kingdom
Aintree University Hospital

Liverpool, L9 7AL, United Kingdom
Beatson West of Scotland Cancer Centre

Glasgow, G12 0YN, United Kingdom
Belfast City Hospital

Belfast, BT9 7AB, United Kingdom
Bradford Royal Infirmary

Bradford, West Yorkshire, BD9 6RJ, United Kingdom
Bristol Haematology and Oncology Centre

Bristol, Bristol, BS2 8ED, United Kingdom
Castle Hill Hospital

Cottingham, East Yorkshire, HU16 5JQ, United Kingdom
Cheltenham General Hospital

Cheltenham, GL53 7AN, United Kingdom
Christie Hospital

Manchester, M20 4BX, United Kingdom
Churchill Hospital

Oxford, Oxfordshire, OX3 7LE, United Kingdom
Clatterbridge Cancer Centre

Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
Colchester General Hospital

Colchester, Essex, CO4 5JL, United Kingdom
Derriford Hospital

Plymouth, United Kingdom
Freeman Hospital

Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom
James Cook University Hospital

Middlesbrough, North Yorkshire, TS4 3BW, United Kingdom
Leicester Royal Infirmary

Leicester, East Midlands, LE1 5WW, United Kingdom
Musgrove Park Hospital

Taunton, TA1 5DA, United Kingdom
Newcross Hospital

Wolverhampton, West Midlands, WV10 OQP, United Kingdom
Norfolk and Norwich University Hospital

Norwich, NR4 7UY, United Kingdom
North Middlesex Hospital

London, London, N18 1QX, United Kingdom
Nottingham City Hospital

Nottingham, Nottingham, NG5 1PB, United Kingdom
Queen Elizabeth Hospital

Birmingham, West Midlands, B15 2TH, United Kingdom
Queen's Hospital

Romford, Essex, RM7 0AG, United Kingdom
Royal Devon and Exeter Hospital

Exeter, Devon, EX2 5DW, United Kingdom
Royal Preston Hospital

Preston, Lancashire, PR2 9HT, United Kingdom
Royal Shrewsbury Hospital

Shrewsbury, SY3 8XQ, United Kingdom
Royal United Hospital

Bath, BA1 3NG, United Kingdom
Singleton Hospital

Swansea, Swansea, SA2 8QA, United Kingdom
St James's Hospital

Dublin, Dublin 8, Ireland
St James's University Hospital

Leeds, West Yorkshire, LS9 7TF, United Kingdom
St Luke's Hospital

Dublin, Dublin 6, Ireland
Torbay Hospital

Torquay, TQ2 7AA, United Kingdom
University Hospital Coventry

Coventry, West Midlands, CV2 2DX, United Kingdom
Velindre Cancer Centre

Cardiff, Cardiff, CF14 2TL, United Kingdom
Western General Hospital

Edinburgh, Edinburgh, EH4 2XU, United Kingdom
Weston Park Hospital

Sheffield, South Yorkshire, S10 2SJ, United Kingdom
York Hospital

York, North Yorkshire, YO31 8HE, United Kingdom

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