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Can tumor genetics unlock gentler treatments for head and neck cancer?

NCT ID NCT06133790

Knowledge-focused Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study investigates whether head and neck cancers caused by HPV have different genetic profiles compared to those linked to alcohol and tobacco use. By analyzing tumor biopsies, researchers aim to identify genetic markers that could predict how well a patient responds to chemotherapy or radiotherapy. The goal is to eventually allow doctors to tailor treatments to each patient's cancer type, potentially making therapy more effective and less invasive.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Genetic analysis of tumor biopsies to define molecular profiles
What this could lead to
If successful, this could identify genetic markers that predict which patients respond best to chemotherapy or radiotherapy, enabling more personalized and less invasive treatment for head and neck cancers.
What could go wrong
This is an early-stage observational study with a small sample size, so findings may not be conclusive or broadly applicable. The analysis is exploratory and may not directly change treatment guidelines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Started

Jan 2024

Expected to finish

Jun 2024

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patient with Head and Neck cancer and HPV diagnosis

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with oropharyngeal squamous cell carcinoma or the oral cavity histologically proven. * Primary tumor for which a biopsy or excision is required available and sufficient to carry out molecular analysis Exclusion Criteria: \- Patient with Head and Neck cancer other than oropharyngeal or oral cavity squamous cells carcinomas

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms oral cavity squamous cell carcinoma oropharynx squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck cancer

Contacts and locations

Locations

  • Hôpital Privé Clairval

    Marseille, 13009, France

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