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Blood biomarkers may foreshadow Radiation-Induced dry mouth

NCT ID NCT06700863

Diagnosis Sponsor: The First Affiliated Hospital with Nanjing Medical University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This study investigates whether blood samples can reveal early warning signs of severe dry mouth in patients receiving radiation for head and neck cancer. Researchers will collect blood before and after treatment and use advanced molecular techniques to search for biomarkers that predict this side effect. The goal is to build a model that identifies at-risk patients early, allowing for preventive care and better quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood sample analysis using multiple omics techniques to identify predictive molecular biomarkers
What this could lead to
If successful, this could enable early detection and intervention for radiation-induced dry mouth, improving quality of life for head and neck cancer patients.
What could go wrong
The study is exploratory and relatively small, so the biomarkers may not prove accurate or generalizable. Also, the research focuses on prediction, not treatment, so benefits depend on future interventions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

May 2024

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Head and neck cancer radiotherapy patients

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histological diagnosis of head and neck cancer; * Plan to undergo curative treatment with radiotherapy alone or in combination with synchronous chemotherapy, immunotherapy, or targeted therapy; * Age greater than or equal to 18 years old, Fully understand the purpose and significance of this study, voluntarily participate and sign an informed consent form. Exclusion Criteria: * Metastatic diseases; * History of head and neck radiotherapy; * Severe dry mouth before radiotherapy; * Suffering from advanced chronic diseases: heart failure - New York Heart Association functional classification III/IV, renal failure - estimated glomerular filtration rate under 30mL/min/1.73m2, liver failure - Child Pugh score C or D.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms Xerostomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Xerostomia due to radiotherapy (disorder)

Contacts and locations

Locations

  • Affiliated Jinling Hospital, Medical School of Nanjing University

    Nanjing, Jiangsu, 450041, China

  • Jiangsu Cancer Hospital

    Nanjing, Jiangsu, China

  • The First Affiliated Hospital of Nanjing Medical University

    Nanjing, Jiangsu, China

  • The Second Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, China

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