University Of Birmingham

This phase II trial tests different drug combinations to prevent graft-versus-host disease (GVHD) in 400 blood cancer patients receiving stem cell transplants from unrelated donors. Participants will receive either thymoglobulin or a combination of cyclophosphamide with other imm…

This phase II trial compares standard chemotherapy with newer drug combinations for people whose follicular lymphoma has returned or stopped responding to treatment. About 284 participants will receive either standard therapy or one of several experimental regimens, including a b…

This phase II trial tests whether adding a cannabis-based mouth spray (nabiximols) to standard chemotherapy helps people with recurrent glioblastoma live longer. About 120 adults whose brain tumor has returned after initial treatment will receive either the cannabis spray or a pl…

This study tests whether ruxolitinib works better than current standard therapies (hydroxycarbamide or interferon alpha) for people with high-risk polycythemia vera, a blood cancer that increases red blood cells. About 586 adults aged 18 and older with high-risk features will be …

This study tests whether transplanting healthy stool bacteria (FMT) can improve liver health in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease. 58 adults will receive either FMT or a placebo via colonoscopy and enemas. The main goal is to see if F…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study is for children and young people with B-cell Non-Hodgkin lymphoma that has come back or not responded to treatment. Current treatments are harsh and only work for about 30 out of 100 children. The trial will test several new medicines, alone or with chemotherapy, to se…

This trial is testing several combinations of existing drugs (dinutuximab beta, bevacizumab, irinotecan, and temozolomide) in children whose neuroblastoma has come back or not responded to standard treatment. About 160 participants will be randomly assigned to different treatment…

This study tests whether drinking whey protein before meals can help adults aged 75-90 with type 2 diabetes keep their blood sugar in a healthy range. Participants will take whey protein or a placebo before each meal for a week, and their blood sugar will be tracked continuously.…

This study tests whether a group therapy program (GTEP) can help reduce trauma symptoms in people who had a traumatic birthing experience. Ten participants will join online sessions and complete questionnaires about their symptoms and well-being. The goal is to see if this approa…

This study tests whether eating grapes rich in flavonoids can protect brain blood flow, thinking, and blood vessel health during mental stress. 44 healthy young adults will consume either a high-flavonoid grape powder or a low-flavonoid placebo before a stress task. The goal is t…

This UK study is building a network to rapidly analyze the genetics of brain tumours (gliomas) from 1000 patients. By combining tumour and blood samples, researchers hope to classify each tumour more precisely. The goal is to create a system that can quickly match patients with t…