University Of Birmingham

This study tests whether ruxolitinib works better than current standard treatments (hydroxycarbamide or interferon) for people with high-risk polycythemia vera, a blood cancer that increases red blood cells. About 586 adults with high-risk disease will be randomly assigned to rux…

This study is for people with follicular lymphoma that has come back or not responded to treatment. It compares new experimental therapies to the current standard care to see which works better. About 284 adults will take part, and the main goal is to see if the new treatments ca…

This study tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy can help people with a returning, aggressive brain tumor (glioblastoma) live longer. About 120 adults whose tumor has returned after initial treatment will be randomly assigned to r…

This study tests whether a fecal microbiota transplant (FMT) can improve liver health in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease. About 58 adults will receive either FMT or a placebo. The main goal is to see if FMT lowers a key liver enzyme…

This study tests three different drug combinations to prevent graft-versus-host disease (GVHD) in 400 people with blood cancers receiving stem cells from unrelated donors. GVHD is a serious complication where donor cells attack the patient's body. The goal is to find which approa…

This study looks at whether drinking whey protein before meals can help older adults (ages 75-90) with type 2 diabetes keep their blood sugar levels steadier throughout the day. Over two 7-day periods, participants will take either a whey protein drink or a placebo before each me…

This study tests new drugs for children and teens with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. Current treatments cure only about 30% of these patients and have harsh side effects. The trial will give participants one of several new medicines…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which is better at preserving vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to…

This study is for children and young adults whose neuroblastoma has come back or not responded to standard treatment. It tests different combinations of drugs to see which works best and is safe. About 160 participants will receive one of three treatment plans, including targeted…

This study tests a group therapy program (GTEP) for people who have had a traumatic birthing experience. Ten participants will attend online group sessions and report changes in trauma symptoms, wellbeing, and bonding with their baby. The goal is to see if this approach is feasib…

This study looks at whether eating grapes rich in natural compounds called flavonoids can protect brain function, blood flow, and mood during mental stress in healthy young adults aged 18-40. Participants will consume either a high-flavonoid grape powder or a low-flavonoid contro…

This study aims to improve how brain tumors (gliomas) are diagnosed and treated by using advanced genetic testing. Researchers will analyze tumor samples from 1,000 participants to identify specific genetic changes and match them with targeted therapies. The goal is to provide mo…