University Of Birmingham

This study tested whether adding the drug bevacizumab (Avastin) to standard chemotherapy helps children with neuroblastoma that has returned or not responded to treatment. The trial enrolled 225 children aged 1 to 21. Researchers looked at tumor shrinkage and how long the disease…

This study tested a drug called sodium valproate in 63 children and adults with Wolfram syndrome, a rare genetic disorder that causes vision loss and other health problems. Participants were randomly assigned to receive either the drug or a placebo to see if it could slow the wor…

This trial tested several targeted drugs in people with non-small cell lung cancer whose tumors had specific genetic changes. The goal was to see if these drugs could shrink tumors or delay cancer growth. Over 400 participants received treatment based on their tumor's genetic pro…

This phase II trial tested the immunotherapy drug nivolumab (Opdivo) in 35 adults with advanced colorectal cancer that has a specific marker (class II expression) and is microsatellite stable, a type that usually does not respond to immunotherapy. The goal was to see if the drug …

This study looked at whether a cocoa drink rich in flavanols (plant compounds) could protect blood vessel health in healthy older adults during 2 hours of sitting. Twenty participants aged 65+ drank either a high-flavanol or low-flavanol cocoa before sitting. Researchers measured…