Poop pills could tame rare liver disease
NCT ID NCT06286709
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether transplanting healthy stool bacteria (FMT) can improve liver health in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease. 58 adults will receive either FMT or a placebo via colonoscopy and enemas. The main goal is to see if FMT lowers a key liver enzyme (ALP) after 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fecal microbiota transplant (FMT)
What this could lead to
If it works, this could point toward a new treatment for primary sclerosing cholangitis (PSC) and related inflammatory bowel disease by restoring gut bacteria balance.
What could go wrong
This is an early phase 2 trial with only 58 participants, so results may not apply to everyone. FMT is generally safe but can cause mild side effects like bloating or infection risk.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust
RECRUITINGOxford, OX3 9DU, United Kingdom
Contact
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King's College Hospital, King's College Hospital NHS Foundation Trust
RECRUITINGLondon, SE5 9RS, United Kingdom
Contact
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Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust
RECRUITINGBirmingham, B15 2TH, United Kingdom
Contact
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Royal Free Hospital, Royal Free London NHS Foundation Trust
RECRUITINGLondon, NW3 2QG, United Kingdom
Contact
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St Mark's Hospital, London North West University Healthcare NHS Trust
RECRUITINGLondon, NW10 7NS, United Kingdom
Contact