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Poop pills could tame rare liver disease

NCT ID NCT06286709

Recruiting now Disease control Sponsor: University of Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether transplanting healthy stool bacteria (FMT) can improve liver health in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease. 58 adults will receive either FMT or a placebo via colonoscopy and enemas. The main goal is to see if FMT lowers a key liver enzyme (ALP) after 48 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
fecal microbiota transplant (FMT)
What this could lead to
If it works, this could point toward a new treatment for primary sclerosing cholangitis (PSC) and related inflammatory bowel disease by restoring gut bacteria balance.
What could go wrong
This is an early phase 2 trial with only 58 participants, so results may not apply to everyone. FMT is generally safe but can cause mild side effects like bloating or infection risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cholangitis, Sclerosing inflammatory bowel disease primary sclerosing cholangitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLAMMATORY BOWEL DISEASES PRIMARY SCLEROSING CHOLANGITIS

Contacts and locations

Locations

  • John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust

    RECRUITING

    Oxford, OX3 9DU, United Kingdom

  • King's College Hospital, King's College Hospital NHS Foundation Trust

    RECRUITING

    London, SE5 9RS, United Kingdom

  • Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust

    RECRUITING

    Birmingham, B15 2TH, United Kingdom

  • Royal Free Hospital, Royal Free London NHS Foundation Trust

    RECRUITING

    London, NW3 2QG, United Kingdom

  • St Mark's Hospital, London North West University Healthcare NHS Trust

    RECRUITING

    London, NW10 7NS, United Kingdom

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