New hope for lymphoma patients: trial pits novel drugs against standard chemo

NCT ID NCT05848765

Recruiting now Disease control Sponsor: University of Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial compares standard chemotherapy with newer drug combinations for people whose follicular lymphoma has returned or stopped responding to treatment. About 284 participants will receive either standard therapy or one of several experimental regimens, including a bispecific antibody and an immunomodulatory drug. The goal is to see if the new approaches lead to better cancer control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Epcoritamab, Lenalidomide, Rituximab, Obinutuzumab, Bendamustine, Vincristine, Doxorubicin, Cyclophosphamide, Prednisone
What this could lead to: If successful, this trial could identify new treatment combinations that work better than standard chemotherapy for people with relapsed follicular lymphoma.
What could go wrong: This is a phase II trial, so results are still early. The new treatments may not prove more effective or could have unexpected side effects. The second experimental drug is not yet confirmed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY FOLLICULAR LYMPHOMA RELAPSED FOLLICULAR LYMPHOMA

Contacts and locations

Locations

Belfast Health & Social Care Trust
NOT_YET_RECRUITING

Belfast, United Kingdom
Blackpool Teaching Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Blackpool, United Kingdom
Cambridge University Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Cambridge, United Kingdom
Cardiff and vale University LHB
NOT_YET_RECRUITING

Cardiff, United Kingdom
Croydon Health Services NHS Trust
NOT_YET_RECRUITING

Croydon, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
NOT_YET_RECRUITING

London, United Kingdom
King's College Hospital NHS Foundation Trust
NOT_YET_RECRUITING

London, United Kingdom
NHS Grampian
NOT_YET_RECRUITING

Aberdeen, United Kingdom
NHS Greater Glasgow and Clyde
NOT_YET_RECRUITING

Glasgow, United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Norwich, United Kingdom
Nottingham University Hospitals NHS Trust
RECRUITING

Nottingham, United Kingdom
Oxford University Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Oxford, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Sheffield, United Kingdom
Swansea Bay University Local Health Board
NOT_YET_RECRUITING

Swansea, United Kingdom
The Christie NHS Foundation Trust
RECRUITING

Manchester, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust
NOT_YET_RECRUITING

Liverpool, United Kingdom
The Leeds Teaching Hospitals NHS Trust
NOT_YET_RECRUITING

Leeds, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Newcastle, United Kingdom
The Royal Marsden NHS Foundation Trust
NOT_YET_RECRUITING

London, United Kingdom
Torbay and South Devon NHS Foundation Trust
NOT_YET_RECRUITING

Torquay, United Kingdom
University College London Hospital NHS Foundation Trust
NOT_YET_RECRUITING

London, United Kingdom
University Hospital Southampton NHS Foundation Trust
NOT_YET_RECRUITING

Southampton, United Kingdom
University Hospital of North Midlands NHS Trust
NOT_YET_RECRUITING

Stoke-on-Trent, United Kingdom
University Hospitals Birmingham NHS Foundation Trust
NOT_YET_RECRUITING

Birmingham, United Kingdom
University Hospitals Coventry and Warwickshire NHS Trust
NOT_YET_RECRUITING

Coventry, United Kingdom

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