New combo shows promise for rare blood cancer

NCT ID NCT03598998

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tested a combination of two drugs (pembrolizumab and pralatrexate) in 13 people with peripheral T-cell lymphoma that had returned or not responded to prior treatment. The goal was to find the safest dose and see if the combo could shrink tumors. The approach uses one drug to block cancer cell growth and another to help the immune system attack the cancer.

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Conditions

The condition(s) this trial relates to.

anaplastic large cell lymphoma angioimmunoblastic T-cell lymphoma enteropathy-associated T-cell lymphoma follicular lymphoma mature T-cell and NK-cell non-Hodgkin lymphoma mycosis fungoides subcutaneous panniculitis-like T-cell lymphoma T-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANAPLASTIC LARGE CELL LYMPHOMA NODAL PERIPHERAL T-CELL LYMPHOMA WITH TFH PHENOTYPE RECURRENT ANAPLASTIC LARGE CELL LYMPHOMA RECURRENT ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA RECURRENT ENTEROPATHY-ASSOCIATED T-CELL LYMPHOMA RECURRENT FOLLICULAR LYMPHOMA RECURRENT HEPATOSPLENIC T-CELL LYMPHOMA RECURRENT MATURE T-CELL AND NK-CELL NON-HODGKIN LYMPHOMA RECURRENT MONOMORPHIC EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA RECURRENT MYCOSIS FUNGOIDES RECURRENT PERIPHERAL T-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY ANAPLASTIC LARGE CELL LYMPHOMA REFRACTORY ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA REFRACTORY ENTEROPATHY-ASSOCIATED T-CELL LYMPHOMA REFRACTORY FOLLICULAR LYMPHOMA REFRACTORY HEPATOSPLENIC T-CELL LYMPHOMA REFRACTORY MATURE T-CELL AND NK-CELL NON-HODGKIN LYMPHOMA REFRACTORY MYCOSIS FUNGOIDES REFRACTORY PERIPHERAL T-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED SUBCUTANEOUS PANNICULITIS-LIKE T-CELL LYMPHOMA

Contacts and locations

Locations

City of Hope Medical Center

Duarte, California, 91010, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

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