OROPHARYNGEAL CANCER

This study tests a combination of three drugs (entinostat, PDS01ADC, and bintrafusp alfa) in adults with advanced cancers linked to HPV or certain colon cancers that haven't responded well to standard treatments. The goal is to find a safe dose and see if the combo can shrink tum…

This study looks at whether giving lower doses of radiation to a smaller area after robotic surgery can still prevent HPV-related throat cancer from coming back. About 150 adults with early-stage cancer will receive this gentler treatment. The goal is to maintain cancer control w…

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) combined with radiation works better than standard chemotherapy (cisplatin) plus radiation for people with advanced head and neck cancer. About 126 participants with p16-positive cancer will be randomly assi…

This study tests whether using MRI scans to plan radiation therapy can allow a lower, safer dose for people with HPV-positive throat cancer. About 90 participants will receive MRI-guided intensity modulated radiotherapy (IMRT) to see if it controls the cancer as well as standard …

This study tests whether a mix of three immunotherapy drugs can shrink tumors in people with advanced HPV-related cancers that have spread or not responded to standard treatments. About 51 adults with cancers like cervical, anal, or throat cancer will receive the drugs for up to …

This study tests an HPV vaccine (PRGN-2009) alone or combined with a drug called M7824 in adults with HPV-positive cancers like cervical, anal, and throat cancers. The goal is to find a safe dose and see if the combination boosts the immune system's attack on tumors. Participants…

This study compares two standard treatments for HPV-related throat cancer: radiation therapy or surgery. The goal is to see which approach leads to better survival and quality of life, especially swallowing function. About 61 adults with early-stage cancer are taking part. Result…

This study tests an immune-boosting drug called BALSTILIMAB in 20 people with HPV-positive oropharyngeal cancer who still have signs of the virus in their blood after finishing standard treatment. The goal is to see if the drug can clear the virus and improve long-term survival. …

This study is testing whether a blood test called NavDx can find early signs of HPV-related throat cancer by looking for tiny pieces of HPV DNA in the blood. The researchers are enrolling adults aged 45 and older who have had multiple sexual partners. The goal is to see how many …

This study looks at whether skipping radiation to some lymph node areas can lower side effects without increasing the chance of the cancer coming back. It includes 103 adults with low-risk HPV-related oropharyngeal cancer. The goal is to see if a smaller radiation field is safe a…

This study tests an online program called Empowered Survivor, designed to help people who have had oral or throat cancer feel more confident managing their health after treatment. About 643 cancer-free survivors will use either the Empowered Survivor tool or a free online program…

This study screens 1500 adults for oral HPV infection and related antibodies to identify those at higher risk for HPV-related throat cancer. Researchers follow participants over time to see which infections persist and what factors (like mouth bacteria or immune response) play a …

This study tests a new program to help head and neck cancer patients who feel depressed. It looks at whether the program is easy to use and if it helps patients follow their swallowing exercises and dental care. About 185 adults with stage I-IV cancer take part. The goal is to se…

This study looks at whether a lower dose of radiation can safely control HPV-positive throat cancer in people who have never smoked or smoked very little. Researchers will follow 75 patients for up to 5 years to see if the cancer stays away and how their quality of life is affect…