OROPHARYNGEAL CANCER

This early-phase trial is testing a new therapeutic HPV vaccine, given alone or combined with an immunotherapy drug called M7824, in people with cancers linked to HPV. The main goals are to find a safe dose and see if the treatments can stimulate the body's immune system to bette…

This study is testing whether a newer immunotherapy drug (pembrolizumab) combined with radiation works better than the current standard treatment of chemotherapy plus radiation for people with advanced head and neck cancer. It will involve 126 patients whose cancer is linked to t…

This study is testing whether doctors can safely give less radiation to certain lymph node areas in patients with a specific type of throat cancer linked to HPV. The goal is to reduce treatment side effects like trouble swallowing and dry mouth without increasing the risk of the …

This study is testing a new combination of three immunotherapy drugs for people with advanced cancers that have not responded well to standard treatments. It focuses on cancers linked to HPV (like cervical, throat, and anal cancers) and certain colon cancers. The main goals are t…

This study is testing whether a lower dose of radiation can safely control HPV-positive throat cancer in people who are non-smokers or minimal smokers. It follows 75 patients for five years to see if the cancer stays away after this 'de-escalated' treatment. The goal is to mainta…

This study is comparing two standard treatments for early-stage throat cancer caused by HPV: surgery and radiation therapy. The goal is to see which approach gives patients the best chance of survival while also preserving their quality of life, like swallowing and speaking. It w…

This study is testing whether using lower doses of radiation to a smaller area of the head and neck can still effectively control cancer after surgery for HPV-positive throat cancer. The goal is to see if this 'de-intensified' approach can maintain good cancer control while poten…

This study is testing whether using MRI scans to guide radiation therapy can allow doctors to safely use lower radiation doses for certain throat cancers. It focuses on patients with HPV-positive throat cancer who have a low risk of the cancer spreading. The goal is to control th…

This study is testing whether a blood test can help find HPV-related throat cancer early. Researchers are enrolling adults aged 45+ with certain sexual histories who have not had this cancer before. The goal is to see if looking for traces of HPV in the blood is a practical way t…

This study is comparing two online programs designed to help people who have finished treatment for oral or throat cancer. It aims to see if a new tool called 'Empowered Survivor' helps people feel more confident managing their health, better prepared for life after cancer, and i…

This study tests whether weekly phone counseling sessions can help reduce depression in people undergoing radiation treatment for head and neck cancer. Researchers want to see if easing depression helps patients stick better to important swallowing exercises and dental care routi…

This study aims to understand why some oral HPV infections last a long time and may lead to throat cancer. Researchers are screening 1,500 adults, then following those with signs of the virus for several years to track their health. The goal is to learn which factors put people a…