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Could less radiation be better for some throat cancer patients?

NCT ID NCT03822897

Ongoing Symptom relief Sponsor: Canadian Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether giving less radiation to the lymph nodes can reduce side effects for people with low-risk HPV-related throat cancer. The goal is to see if doctors can safely skip radiation to some lymph node areas without increasing the chance of the cancer coming back. About 100 patients are taking part, and they receive either radiation alone or radiation plus chemotherapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Radiation therapy (with or without cisplatin chemotherapy)
What this could lead to
If successful, this could lead to a standard treatment that reduces side effects for patients with low-risk HPV-related throat cancer, improving quality of life without compromising cancer control.
What could go wrong
This is a phase 2 trial with only 103 participants, so results may not apply to all patients. Reducing radiation might increase the risk of cancer returning in the lymph nodes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

human papillomavirus-related squamous cell carcinoma oropharyngeal carcinoma oropharynx cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OROPHARYNGEAL CANCER

Contacts and locations

Locations

  • Allan Blair Cancer Centre

    Regina, Saskatchewan, S4T 7T1, Canada

  • BCCA - Centre for the North

    Prince George, British Columbia, V2M 7E9, Canada

  • BCCA - Vancouver Cancer Centre

    Vancouver, British Columbia, V5Z 4E6, Canada

  • CIUSSS de l'Estrie - Centre hospitalier

    Sherbrooke, Quebec, J1H 5N4, Canada

  • CancerCare Manitoba

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Dr. H. Bliss Murphy Cancer Centre

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

  • Hotel-Dieu de Quebec

    Québec, Quebec, G1R 2J6, Canada

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario, L8V 5C2, Canada

  • Kingston Health Sciences Centre

    Kingston, Ontario, K7L 2V7, Canada

  • Odette Cancer Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Ottawa Hospital Research Institute

    Ottawa, Ontario, K1H 8L6, Canada

  • The Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • The Research Institute of the McGill University

    Montreal, Quebec, H4A 3J1, Canada

  • University Health Network

    Toronto, Ontario, M5G 2M9, Canada

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