Cold hands, healthy nerves? study tests cryotherapy to block chemo side effect

NCT ID NCT06281925

Terminated Prevention Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether wearing cold gloves during chemotherapy can prevent peripheral neuropathy (nerve damage causing numbness, tingling, or pain) in colon cancer patients. Forty adults with stage III colon cancer who are about to start a common chemo regimen (CAPOX) will be randomly assigned to use cryotherapy gloves or not. The goal is to see if the cold treatment reduces the number of people who develop nerve problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cryotherapy gloves (cold packs in fabric gloves)
What this could lead to: If it works, this could offer a simple, drug-free way to prevent painful nerve damage from chemotherapy, improving quality of life for colon cancer patients.
What could go wrong: This is a small pilot study with only 40 people, and it is currently suspended. The results may not apply to everyone, and the benefit may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm peripheral nervous system disorder peripheral neuropathy chemotherapy-induced neuropathy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLON CANCER PERIPHERAL NEUROPATHY

Contacts and locations

Locations

NYU Langone Health

Mineola, New York, 11501, United States
NYU Langone Health

New York, New York, 10016, United States

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