PERIPHERAL NEUROPATHY

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study tests whether desloratadine, a common allergy medication, can prevent nerve damage caused by taxane chemotherapy in breast cancer patients. About 116 participants will receive either desloratadine or a placebo for 12 weeks while on chemotherapy. The goal is to see if t…

This study tests whether taking fish oil supplements can prevent nerve damage in the hands and feet caused by oxaliplatin chemotherapy in colorectal cancer patients. 120 participants will receive either fish oil or corn oil (placebo) during their treatment. The goal is to see if …

This study tests a device called Walkasins, worn on the lower legs, that vibrates to give sensory feedback about foot pressure. The goal is to see if using it daily for six months improves balance and walking in 200 adults aged 55+ with peripheral neuropathy. Participants will do…

This pilot study tests whether Tai Chi, alpha-lipoic acid supplements, and acupuncture can help ease chemotherapy-induced peripheral neuropathy (nerve pain, numbness, tingling) in people with gastrointestinal cancer. About 60 participants will try one or more of these approaches …

This study looks at whether using a nerve stimulator in short bursts (30 seconds on, 90 seconds off) can provide the same or better pain relief as continuous stimulation. It involves 30 adults who have had a dorsal root ganglion stimulator for at least a year and report at least …

This study tests whether a non-invasive magnetic stimulation device (AtMS) can reduce nerve pain caused by injury or surgery in veterans and active-duty military. 180 participants will receive either active, fixed, or sham stimulation over 16 weeks. Researchers will measure pain,…

This study tests whether fenofibrate, a drug typically used for high cholesterol, can prevent or reduce nerve damage caused by a common chemotherapy regimen for multiple myeloma. The trial will enroll 44 newly diagnosed patients, half receiving fenofibrate alongside their standar…

This study looks at how nerves are affected in people who develop nerve damage from the chemotherapy drug cisplatin. Researchers will use a special test to measure nerve activity and compare it to normal nerves. The goal is to better understand this side effect and find early war…

This study uses ultrasound, a safe imaging technique that uses sound waves, to get detailed pictures and measurements of nerves and muscles. Researchers aim to collect normal values from healthy adults and compare them with data from people who have neuromuscular disorders. The g…

This study is investigating whether the hormone amylin, which is elevated in type 2 diabetes, is linked to peripheral neuropathy (nerve damage). Researchers will collect blood and skin samples from 40 adults with type 2 diabetes and mild-to-severe neuropathy. They will measure am…

This study follows 20 people with a rare nerve disease called CMT4J for up to 2 years. Researchers will track symptoms and health changes to better understand how the disease progresses. The goal is to find better ways to measure the disease, which could help design future treatm…

This study checks if special sensors can reliably measure forces inside carbon fiber ankle-foot braces (orthoses). Researchers will test healthy volunteers and people with or without neuropathy who already use such braces. Participants will walk, sit, and stand while sensors reco…

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …

This study looks at whether ultrasound can detect nerve changes in people with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) earlier than standard tests. Researchers will compare ultrasound images with nerve conduction studies …

This study looks at why many people with Waldenström's macroglobulinemia, a rare blood cancer, develop nerve damage that can cause pain, numbness, and trouble moving. Researchers will examine 90 patients to find out how common this nerve damage is and what causes it. The goal is …