Could a hormone be the hidden cause of diabetic nerve pain?

NCT ID NCT03481283

Recruiting now Knowledge-focused Sponsor: Zabeen Mahuwala, MD Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is investigating whether the hormone amylin, which is elevated in type 2 diabetes, is linked to peripheral neuropathy (nerve damage). Researchers will collect blood and skin samples from 40 adults with type 2 diabetes and mild-to-severe neuropathy. They will measure amylin levels in red blood cells and blood vessel walls, then compare them to nerve function and pain sensitivity. The goal is to see if higher amylin levels are associated with worse nerve symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If a link is found, this could point toward new ways to detect or treat diabetic nerve damage.
What could go wrong: This is a small, early observational study. It only looks for a correlation, not a cause, and may not lead to any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

peripheral nervous system disorder peripheral neuropathy type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL NEUROPATHY TYPE2 DIABETES

Contacts and locations

Locations

UK Robert Straus Behavioral Science Laboratory
ACTIVE_NOT_RECRUITING

Lexington, Kentucky, 40508, United States
University of Kentucky - Kentucky Neuroscience Institute
RECRUITING

Lexington, Kentucky, 40536, United States

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