Fish oil may shield cancer patients from chemo nerve pain

NCT ID NCT05404230

Recruiting now Prevention Sponsor: Vejle Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking fish oil supplements can prevent nerve damage in the hands and feet caused by oxaliplatin chemotherapy in colorectal cancer patients. 120 participants will receive either fish oil or corn oil (placebo) during their treatment. The goal is to see if fish oil reduces the number of patients who develop painful nerve symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fish oil (polyunsaturated fatty acids)
What this could lead to: If it works, this could provide a simple, low-cost way to prevent painful nerve damage from oxaliplatin chemotherapy.
What could go wrong: This is a small, early-stage trial with only 120 participants. The benefit may be small or not work at all, and fish oil supplements can cause mild side effects like fishy aftertaste or stomach upset.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm peripheral nervous system disorder peripheral neuropathy chemotherapy-induced neuropathy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER PERIPHERAL NEUROPATHY

Contacts and locations

Locations

Department of Oncology
RECRUITING

Sønderborg, Denmark
Department of Oncology, AAUH
RECRUITING

Aalborg, Denmark
Department of Oncology, AUH
RECRUITING

Aarhus, Denmark
Department of Oncology, Vejle Hospital
RECRUITING

Vejle, Denmark

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