New hope for Hard-to-Treat cancers: targeted drug enters human testing
NCT ID NCT05485974
First seen Oct 31, 2025 · Last updated May 13, 2026 · Updated 26 times
Summary
This early-phase study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic change called KRAS G12C. The main goal is to find the safest dose and check for side effects. About 44 adults who have tried other treatments without success will take part.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Alliance for Multispecialty Research, LLC
Kansas City, Missouri, 64114, United States
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BRCR Medical Center
Plantation, Florida, 33322, United States
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California Cancer Associates for Research and Excellence, Inc. (cCare)
Encinitas, California, 92024, United States
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California Cancer Associates for Research and Excellence, Inc. (cCare)
San Marcos, California, 92069, United States
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Gabrail Cancer Center
Canton, Ohio, 44718, United States
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Innovative Clinical Research Institute (ICRI)
Whittier, California, 90603, United States
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Michigan Center of Medical Research
Farmington Hills, Michigan, 48334, United States
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Pan American Center for Oncology Trials (PanOncology Trials)
Rio Piedras, Puerto Rico, 00935, Puerto Rico
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Sarcoma Oncology
Santa Monica, California, 90403, United States
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The Oncology Institute of Hope and Innovation
Glendale, California, 91204, United States
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The Oncology Institute of Hope and Innovation
Long Beach, California, 90805, United States
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The Oncology Institute of Hope and Innovation
Pasadena, California, 91105, United States
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The Oncology Institute of Hope and Innovation
Santa Ana, California, 92705, United States
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The Oncology Institute of Hope and Innovation
Whittier, California, 90603, United States
Conditions
Explore the condition pages connected to this study.