COLON CANCER

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop them from growing. Results will help determine if further testin…

This early-phase study tested a combination of two drugs, regorafenib and nivolumab, in 52 people with advanced colorectal cancer that had stopped responding to other treatments. The goal was to find the safest dose and see if the combination could help control the cancer. The st…

This study tested a combination of three drugs (encorafenib, binimetinib, and cetuximab) given before surgery to people with a specific type of colorectal cancer that has a BRAF V600E mutation. The goal was to see how much the tumor shrank and to check for side effects. Only 2 pe…

This study looked at whether taking daily aspirin and vitamin D, along with exercise and a low-fat diet, could help prevent colorectal cancer from returning in 16 patients who had no visible cancer but still had signs of cancer DNA in their blood. The goal was to see if these lif…

This study tested a combination of two drugs, palbociclib and cetuximab, in 24 adults with metastatic colon cancer that had certain gene types (KRAS/NRAS/BRAF wild-type). The goal was to see if the combo could shrink or stabilize tumors. The study is complete, but results are not…

This early-phase study tested an experimental drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal was to see if the combination is safe and to find the best dose. Researchers als…

This trial tested a new treatment for people with advanced gastrointestinal cancers that had spread and stopped responding to standard therapy. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to boost their cancer-fighting ability, and then infused th…

This study looked at 75 people with advanced colorectal cancer who had already tried standard treatments. Researchers wanted to see if adding the arthritis drug Celebrex to the experimental drug EPO906 could reduce severe diarrhea, a common side effect. The goal was to find the s…

This early-stage study tested the safety of a new drug called COM902, given alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, or colon cancer that had stopped responding to standard treatments. The main goal was to find a safe dose and check for si…

This early-phase study tested a combination therapy in 15 people with colon cancer who had completed standard treatment but still had tiny amounts of cancer DNA in their blood (called minimal residual disease). The treatment used specially activated immune cells from donated umbi…

This study tested a new blood test designed to catch colorectal cancer early in people at average risk. Nearly 49,000 adults aged 45-85 gave a blood sample before their routine screening colonoscopy. The goal was to see how accurately the blood test could detect cancer and advanc…

This study looked at three screening methods—colonoscopy, a camera-in-a-pill (colon capsule), and a stool test—to find colorectal cancer or pre-cancerous growths in people aged 45 and older who have a parent, sibling, or child with colorectal cancer. The goal was to see if the si…

This study tested whether offering a simple blood test (Guardant SHIELD) helps more people complete colorectal cancer screening compared to usual care. About 2,000 adults aged 45-75 who had not returned their stool test took part. The main goal was to see how many got screened wi…

This study compared two ways to manage pain during and after colorectal surgery: a TAP block (an injection into the abdominal wall) versus epidural anesthesia (an injection near the spine). About 200 adults having elective colon or rectal surgery for cancer or diverticulitis took…

This study compared two standard pain relief methods after colon or rectal surgery: continuous preperitoneal analgesia (using a catheter placed near the surgical site) and continuous epidural analgesia (a catheter placed near the spine). 98 adults having elective colon or rectal …

This study looked at whether a high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. The trial included 80 adults with a STOP…

This study looked at whether a supervised exercise program can help people with breast or colon cancer feel better and have a better quality of life. 78 patients took part, some of whom were also receiving chemotherapy, radiotherapy, or hormonal therapy. The program lasted 6 week…

This study tested a web app called PrehabPal that helps people aged 65 and older prepare for colon cancer surgery. The app creates a personalized exercise and health plan and offers coaching before surgery. Researchers compared it to written instructions to see if it helps patien…

This study tested a personalized rehabilitation program for 150 adults who finished treatment for colorectal cancer. The program connects patients with specialists like physiotherapists, dietitians, and psychologists based on their individual needs. The goal was to improve qualit…

This study involved 170 patients aged 75 and older with stage III colon cancer who had surgery. Researchers wanted to see how well they tolerated chemotherapy by measuring changes in daily living activities. They also looked at gene signatures to predict outcomes and improve pati…

This study looked at 1,471 people with colon cancer to see if a DNA repair feature (called MMR status) affects how cancer spreads to lymph nodes and how long patients live. Researchers compared two groups: those with normal repair (pMMR) and those with faulty repair (dMMR). The g…

This study followed over 3,600 people with early to mid-stage colon cancer who had surgery to remove their tumor. Researchers tracked where cancer had spread to nearby lymph nodes and how much bowel and surrounding tissue was removed. The goal was to learn which surgical approach…

This study tested whether a church-based educational program could increase colorectal cancer knowledge and willingness to join cancer clinical trials among 60 Spanish-speaking Latino adults. Participants watched videos and completed surveys over a month. The goal was to identify…

This study measured how common muscle loss (sarcopenia) is in 70 people before colorectal cancer surgery and tracked their recovery. Researchers found that those with sarcopenia had more complications and longer hospital stays. The goal is to help identify high-risk patients who …

This study looked at whether using a physical activity screener, along with exercise coaching and self-monitoring, could help breast and colon cancer survivors become more active and spend less time sitting. Twenty survivors who had finished their main cancer treatment at least t…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study tested whether doctors can tell the difference between real endoscopic images and AI-transformed ones. 40 physicians with colonoscopy experience viewed different image styles. The goal is to help AI systems work better with various equipment. No treatment was given; it…

This study looked at how DNA from tumors changes in the blood before, during, and after surgery for breast, prostate, or colon cancer. Thirty adults having curative surgery provided blood samples to measure these DNA levels. The goal was to understand the natural pattern of DNA c…

This study tested a 12-week web-based diet program with text messaging for 50 colorectal cancer survivors. The goal was to see if the program was easy to use and could help people eat more vegetables and whole grains while cutting back on red meat and sweets. Participants receive…

This study looked at whether sending text message reminders helps more people finish a simple at-home colon cancer test (called FIT) compared to the usual phone call reminders. Over 1,200 adults from NYU family health centers took part. The goal was to see if texts could boost sc…

This study looked at how Mexican-American families discuss their risk for diseases like diabetes, heart disease, and certain cancers. Researchers interviewed 498 adults from the same households to understand how culture and family ties help or hinder these conversations. The goal…

This study looked at over 7,000 people who had surgery for early-stage colon cancer to see how the tumor stage and lymph node involvement affect the chance of cancer returning and survival. Researchers grouped patients by tumor depth and lymph node status and tracked recurrence p…

This study looked at how closely eight hospitals in Rome follow Enhanced Recovery After Surgery (ERAS) protocols for people having colorectal surgery for cancer or diverticulum. Researchers reviewed the records of 1,000 patients to see which recovery steps were used and how that …

This pilot study tested whether a mindfulness program could help reduce colorectal cancer risk factors in Black women aged 45-65 who live in high-crime Chicago neighborhoods and have had a colon polyp. Twenty-four women participated to see if the program was feasible and acceptab…

This study looked at 1500 people with colon cancer to see if a new system for classifying lymph node spread could better predict survival than the current standard. Researchers tracked the location and number of cancer-affected lymph nodes and tumor deposits. The goal was to impr…

This study looked at 320 men to see whether a digital rectal exam works better when the patient lies on their side or on their back. The goal was to find which position lets doctors feel the entire rectum and check the sphincter more fully. Results will help guide how this common…