Gene-Edited immune cells take on stomach and colon cancers

This study tested a new treatment for people with advanced gastrointestinal cancers (like stomach, colon, or pancreatic cancer) that had spread and stopped responding to standard therapy. Doctors took immune cells from each patient's tumor, used CRISPR gene editing to remove a gene called CISH (which can slow down immune attack), and then infused the boosted cells back into the patient. The goal was to see if this approach was safe and could shrink tumors. The trial involved 23 participants and was completed.