GASTROINTESTINAL NEOPLASMS

This study is testing whether a new drug, PF-08634404, works better than the current standard treatment for people whose colorectal cancer has spread. About 800 adults who haven't yet received treatment for their advanced cancer will be randomly assigned to get either the new dru…

This is the first-ever study in people for an experimental pill called IDRX-42. It aims to find a safe dose and see if it can help control advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The study will enroll adults whose cancer h…

This study is testing a new drug called GSK5764227 for people with advanced stomach, colon, rectal, or pancreatic cancers that have spread and cannot be removed by surgery. The trial aims to see if the drug is safe, how well it works to shrink tumors, and how the body processes i…

This is the first study in people of an experimental drug called JNJ-89402638 for advanced colorectal and stomach cancers that have spread and stopped responding to standard treatments. The main goals are to find a safe dose and see how the body handles the drug, both alone and w…

This study is testing whether a new drug called IDRX-42 works better than the current standard drug, sunitinib, for people with advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The trial will involve 450 adults whose cancer has pro…

This study is testing a new camera-based method (iPPG) against the current standard dye method (ICG) to see which is better at checking blood flow in tissue during surgery for stomach or colorectal cancer. The goal is to help surgeons make better decisions during the operation to…

This study is testing whether virtual reality (VR) can help reduce pain and improve quality of life for people with gastrointestinal cancers. Researchers will compare three approaches: VR that teaches pain management skills, VR designed to distract from pain, and a basic VR contr…

This study is testing if a fecal microbiota transplant (FMT), which transfers healthy gut bacteria from a donor, can help reduce nausea, vomiting, and diarrhea caused by chemotherapy or targeted therapy. It will involve 90 adults with advanced gastrointestinal cancers who have al…

This study aims to understand if taking chemotherapy as a pill versus through an IV affects sleep quality and depression levels in patients with non-metastatic gastrointestinal cancers. Researchers will follow 82 patients, measuring their sleep and mood at the start of treatment …

This study is testing whether artificial intelligence (AI) software can help doctors better detect and identify early-stage growths in the stomach and colon during routine camera examinations. It involves about 1,650 adults who are already scheduled for a standard endoscopy. The …