New Light-Based imaging could replace dye in surgery to prevent dangerous leaks

NCT ID NCT06222645

Recruiting now Diagnosis Sponsor: Saint Petersburg State University, Russia Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new imaging technique called iPPG, which uses light to measure blood flow, against the standard method using a green dye (ICG) during gastrointestinal surgery. The goal is to see if iPPG can predict and prevent anastomotic leaks—a serious complication where the surgical connection leaks. About 200 adults having elective bowel surgery will be randomly assigned to one of the two imaging methods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Indocyanine Green (ICG) dye and photoplethysmography (iPPG) imaging
What this could lead to: If successful, this could provide a safer, dye-free way to assess blood flow during surgery, potentially reducing complications like anastomotic leaks.
What could go wrong: This is a single-center trial with 200 participants, so results may not apply broadly. The new iPPG method is still experimental and may not be as accurate as the standard ICG approach.

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Conditions

The condition(s) this trial relates to.

Anastomotic Leak colorectal cancer colorectal neoplasm digestive system neoplasm gastric cancer gastric neoplasm Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANASTOMOSIS COLORECTAL CANCER GASTRIC CANCER (GC) GASTROINTESTINAL NEOPLASMS PERFUSION POSTOPERATIVE COMPLICATIONS

Contacts and locations

Locations

Department of Faculty Surgery, Saint Petersburg State University
RECRUITING

Saint Petersburg, Leningradskaya Oblast', 199034, Russia
High-Tech Clinic Beloostrov
ACTIVE_NOT_RECRUITING

Saint Petersburg, Leningradskaya Oblast', 197729, Russia
Shandong Linglong Yingcheng Hospital
RECRUITING

Yantai, Shandong, 265400, China

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