New hope for Tough-to-Treat gut cancer: experimental drug takes on standard therapy

NCT ID NCT07218926

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug, IDRX-42, against the current standard drug sunitinib in adults with advanced gastrointestinal stromal tumors (GIST) that have spread or can't be removed by surgery and have already been treated with imatinib. About 450 participants will be randomly assigned to receive either IDRX-42 or sunitinib to see which better delays cancer growth and improves survival. The study is open-label, meaning both doctors and patients know which treatment is given.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

digestive system neoplasm gastrointestinal stromal tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROINTESTINAL NEOPLASMS

Contacts and locations

Locations

GSK Investigational Site
RECRUITING

Phoenix, Arizona, 85054, United States
GSK Investigational Site
RECRUITING

La Jolla, California, 92093, United States
GSK Investigational Site
RECRUITING

Los Angeles, California, 90048, United States
GSK Investigational Site
RECRUITING

San Francisco, California, 94158, United States
GSK Investigational Site
RECRUITING

New Haven, Connecticut, 06520, United States
GSK Investigational Site
RECRUITING

Jacksonville, Florida, 41076, United States
GSK Investigational Site
RECRUITING

Miami, Florida, 33136, United States
GSK Investigational Site
RECRUITING

Orlando, Florida, 32806, United States
GSK Investigational Site
RECRUITING

Tampa, Florida, 33612, United States
GSK Investigational Site
RECRUITING

Iowa City, Iowa, 52242, United States
GSK Investigational Site
RECRUITING

Overland Park, Kansas, 66210, United States
GSK Investigational Site
RECRUITING

Boston, Massachusetts, 02114-2696, United States
GSK Investigational Site
RECRUITING

Boston, Massachusetts, 02215, United States
GSK Investigational Site
RECRUITING

Ann Arbor, Michigan, 48109, United States
GSK Investigational Site
RECRUITING

Rochester, Minnesota, 55905, United States
GSK Investigational Site
RECRUITING

St Louis, Missouri, 63108, United States
GSK Investigational Site
RECRUITING

Omaha, Nebraska, 68130, United States
GSK Investigational Site
RECRUITING

Lake Success, New York, 11042, United States
GSK Investigational Site
RECRUITING

New York, New York, 10032, United States
GSK Investigational Site
RECRUITING

New York, New York, 10065, United States
GSK Investigational Site
RECRUITING

Rochester, New York, 14642, United States
GSK Investigational Site
RECRUITING

Durham, North Carolina, 27710, United States
GSK Investigational Site
RECRUITING

Columbus, Ohio, 43210, United States
GSK Investigational Site
RECRUITING

Portland, Oregon, 97239, United States
GSK Investigational Site
RECRUITING

Philadelphia, Pennsylvania, 19106, United States
GSK Investigational Site
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
GSK Investigational Site
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
GSK Investigational Site
RECRUITING

Spartanburg, South Carolina, 29307, United States
GSK Investigational Site
RECRUITING

Knoxville, Tennessee, 37920, United States
GSK Investigational Site
RECRUITING

Dallas, Texas, 75246, United States
GSK Investigational Site
RECRUITING

Houston, Texas, 77030, United States
GSK Investigational Site
RECRUITING

Santa Monica, Texas, 90404, United States
GSK Investigational Site
RECRUITING

Salt Lake City, Utah, 84106, United States
GSK Investigational Site
RECRUITING

Charlottesville, Virginia, 22903, United States
GSK Investigational Site
RECRUITING

Seattle, Washington, 98109, United States
GSK Investigational Site
RECRUITING

Tacoma, Washington, 98405, United States
GSK Investigational Site
RECRUITING

Garran, Australian Capital Territory, 2605, Australia
GSK Investigational Site
RECRUITING

Westmead, New South Wales, 2145, Australia
GSK Investigational Site
RECRUITING

Melbourne, Victoria, 3004, Australia
GSK Investigational Site
RECRUITING

Leuven, 3000, Belgium
GSK Investigational Site
RECRUITING

Barretos, São Paulo, 14784-400, Brazil
GSK Investigational Site
RECRUITING

São Caetano do Sul, São Paulo, 09541-270, Brazil
GSK Investigational Site
RECRUITING

Porto Alegre, 90020-090, Brazil
GSK Investigational Site
RECRUITING

Recife, 50040000, Brazil
GSK Investigational Site
RECRUITING

Vitória, 29043-260, Brazil
GSK Investigational Site
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
GSK Investigational Site
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
GSK Investigational Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
GSK Investigational Site
RECRUITING

Shanghai, Shanghai Municipality, 201315, China
GSK Investigational Site
RECRUITING

Beijing, 100036, China
GSK Investigational Site
RECRUITING

Hangzhou, 310016, China
GSK Investigational Site
RECRUITING

Jinan, 250021, China
GSK Investigational Site
RECRUITING

Shanghai, 200127, China
GSK Investigational Site
RECRUITING

Wuhan, 430022, China
GSK Investigational Site
RECRUITING

Angers, 49055, France
GSK Investigational Site
RECRUITING

Bordeaux, 33076, France
GSK Investigational Site
RECRUITING

Lille, 59000, France
GSK Investigational Site
RECRUITING

Lyon, 69373, France
GSK Investigational Site
RECRUITING

Marseille, 13005, France
GSK Investigational Site
RECRUITING

Saint-Herblain, 44805, France
GSK Investigational Site
RECRUITING

Toulouse, 31059, France
GSK Investigational Site
RECRUITING

Villejuif, 94805, France
GSK Investigational Site
RECRUITING

Berlin, Germany
GSK Investigational Site
RECRUITING

Essen, 45122, Germany
GSK Investigational Site
RECRUITING

Mannheim, 68167, Germany
GSK Investigational Site
RECRUITING

Pécs, 7624, Hungary
GSK Investigational Site
RECRUITING

Meldola, FC, 47014, Italy
GSK Investigational Site
RECRUITING

Rozzano MI, Lombardy, 20089, Italy
GSK Investigational Site
RECRUITING

Bari, Italy
GSK Investigational Site
RECRUITING

Candiolo, 10060, Italy
GSK Investigational Site
RECRUITING

Genova, 16132, Italy
GSK Investigational Site
RECRUITING

Milan, 20133, Italy
GSK Investigational Site
RECRUITING

Milan, 20141, Italy
GSK Investigational Site
RECRUITING

Palermo, Italy
GSK Investigational Site
RECRUITING

Roma, 00128, Italy
GSK Investigational Site
RECRUITING

Chiba, 277-8577, Japan
GSK Investigational Site
RECRUITING

Ehime, 791-0280, Japan
GSK Investigational Site
RECRUITING

Fukuoka, 812-8582, Japan
GSK Investigational Site
RECRUITING

Hokkaido, 060-8648, Japan
GSK Investigational Site
RECRUITING

Kanagawa, 247-8533, Japan
GSK Investigational Site
RECRUITING

Kumamoto, 860-8556, Japan
GSK Investigational Site
RECRUITING

Miyagi, 980-8574, Japan
GSK Investigational Site
RECRUITING

Osaka, 565-0871, Japan
GSK Investigational Site
RECRUITING

Tokyo, 104-0045, Japan
GSK Investigational Site
RECRUITING

Tokyo, 135-8550, Japan
GSK Investigational Site
RECRUITING

Nijmegen, 6525 GA, Netherlands
GSK Investigational Site
RECRUITING

Oslo, 0379, Norway
GSK Investigational Site
RECRUITING

Kielce, 25-640, Poland
GSK Investigational Site
RECRUITING

Poznan, 60-569, Poland
GSK Investigational Site
RECRUITING

Warsaw, 02-781, Poland
GSK Investigational Site
RECRUITING

Bucharest, 013823, Romania
GSK Investigational Site
RECRUITING

Bucharest, 022328, Romania
GSK Investigational Site
RECRUITING

Craiova, 200542, Romania
GSK Investigational Site
RECRUITING

Timișoara, 300166, Romania
GSK Investigational Site
RECRUITING

Daegu, 41404, South Korea
GSK Investigational Site
RECRUITING

Seongnam-si Gyeonggi-do, 463 707, South Korea
GSK Investigational Site
RECRUITING

Seoul, 03080, South Korea
GSK Investigational Site
RECRUITING

Seoul, 06351, South Korea
GSK Investigational Site
RECRUITING

Seoul, 120-752, South Korea
GSK Investigational Site
RECRUITING

Seoul, 138-736, South Korea
GSK Investigational Site
RECRUITING

Suwon Kyunggi-do, 16499, South Korea
GSK Investigational Site
RECRUITING

Yangsan, 626-770, South Korea
GSK Investigational Site
RECRUITING

Barcelona, 08025, Spain
GSK Investigational Site
RECRUITING

Barcelona, 08035, Spain
GSK Investigational Site
RECRUITING

Madrid, 28007, Spain
GSK Investigational Site
RECRUITING

Madrid, 28040, Spain
GSK Investigational Site
RECRUITING

Madrid, 28040, Spain
GSK Investigational Site
RECRUITING

Oviedo, 33006, Spain
GSK Investigational Site
RECRUITING

Seville, 41013, Spain
GSK Investigational Site
RECRUITING

Valencia, 46009, Spain
GSK Investigational Site
RECRUITING

Zaragoza, 50009, Spain
GSK Investigational Site
RECRUITING

Changhua, 500, Taiwan
GSK Investigational Site
RECRUITING

Kaohsiung City, 807, Taiwan
GSK Investigational Site
RECRUITING

Kaohsiung City, 833, Taiwan
GSK Investigational Site
RECRUITING

Taipei, 100, Taiwan
GSK Investigational Site
RECRUITING

Taipei, 112, Taiwan
GSK Investigational Site
RECRUITING

Taoyuan, 333, Taiwan
GSK Investigational Site
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
GSK Investigational Site
RECRUITING

Edinburgh, EH4 2XR, United Kingdom
GSK Investigational Site
RECRUITING

Leeds, LS9 8FF, United Kingdom
GSK Investigational Site
RECRUITING

London, NW12BU, United Kingdom
GSK Investigational Site
RECRUITING

London, SW3 6JJ, United Kingdom
GSK Investigational Site
RECRUITING

Manchester, M20 4BX, United Kingdom
GSK Investigational Site
RECRUITING

Sheffield, S10 2SE, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.