New hope for stomach and bowel cancers? experimental drug enters human trials
NCT ID NCT06885034
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an experimental drug called GSK5764227, given alone or with other treatments, in 320 people with advanced gastrointestinal cancers that have not responded to prior therapy. The main goal is to see if the drug can shrink tumors and how safe it is. It is an early-stage trial, so results will help determine if larger studies are warranted.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
GSK5764227 (an experimental biologic drug)
What this could lead to
If successful, this could point toward a new treatment option for people with advanced gastrointestinal cancers that have stopped responding to prior therapies.
What could go wrong
This is an early-phase trial (Phase 1/2) with a small number of participants, so the drug may not work as hoped or could have unexpected side effects. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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GSK Investigational Site
RECRUITINGLos Alamitos, California, 90720, United States
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GSK Investigational Site
RECRUITINGWhittier, California, 90602, United States
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GSK Investigational Site
RECRUITINGNew York, New York, 10065, United States
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GSK Investigational Site
RECRUITINGDurham, North Carolina, 27710, United States
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GSK Investigational Site
RECRUITINGHouston, Texas, 77479, United States
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GSK Investigational Site
RECRUITINGSan Antonio, Texas, 78229, United States
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GSK Investigational Site
RECRUITINGWenatchee, Washington, 98801, United States
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GSK Investigational Site
RECRUITINGHeidelberg, Victoria, 3084, Australia
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GSK Investigational Site
RECRUITINGMelbourne, Victoria, 3000, Australia
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GSK Investigational Site
RECRUITINGBonheiden, 2820, Belgium
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GSK Investigational Site
RECRUITINGBrussels, 1200, Belgium
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GSK Investigational Site
RECRUITINGLeuven, 3000, Belgium
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GSK Investigational Site
RECRUITINGRoeselare, 8800, Belgium
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GSK Investigational Site
RECRUITINGPorto Alegre, 90850-170, Brazil
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GSK Investigational Site
RECRUITINGSão Paulo, 01246-000, Brazil
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GSK Investigational Site
RECRUITINGTeresina, 64049-200, Brazil
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GSK Investigational Site
RECRUITINGToronto, Ontario, M5G 2M9, Canada
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GSK Investigational Site
RECRUITINGSherbrooke, Quebec, J1H 5N4, Canada
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GSK Investigational Site
RECRUITINGParis, 75010, France
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GSK Investigational Site
RECRUITINGParis, 75012, France
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GSK Investigational Site
RECRUITINGVillejuif, 94805, France
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GSK Investigational Site
RECRUITINGPisa, 56126, Italy
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GSK Investigational Site
RECRUITINGAichi, 464-8681, Japan
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GSK Investigational Site
RECRUITINGChiba, 277-8577, Japan
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GSK Investigational Site
RECRUITINGHokkaido, 060-8648, Japan
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GSK Investigational Site
RECRUITINGOsaka, 565-0871, Japan
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GSK Investigational Site
RECRUITINGTokyo, 104-0045, Japan
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GSK Investigational Site
RECRUITINGTokyo, 135-8550, Japan
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GSK Investigational Site
RECRUITINGAmsterdam, 1066 CX, Netherlands
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GSK Investigational Site
RECRUITINGUtrecht, 3584 CX, Netherlands
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GSK Investigational Site
RECRUITINGLrenskog, 1474, Norway
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GSK Investigational Site
RECRUITINGOslo, 0407, Norway
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GSK Investigational Site
RECRUITINGStavanger, 4011, Norway
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GSK Investigational Site
RECRUITINGBrzozów, 36-200, Poland
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GSK Investigational Site
RECRUITINGWarsaw, 02-034, Poland
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GSK Investigational Site
RECRUITINGSeoul, 110 744, South Korea
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GSK Investigational Site
RECRUITINGSeoul, 135-710, South Korea
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GSK Investigational Site
RECRUITINGSeoul, 138-736, South Korea
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GSK Investigational Site
RECRUITINGBarcelona, 08041, Spain
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GSK Investigational Site
RECRUITINGMadrid, 28007, Spain
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GSK Investigational Site
RECRUITINGMadrid, 28034, Spain
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GSK Investigational Site
RECRUITINGMadrid, 28041, Spain
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GSK Investigational Site
RECRUITINGPamplona, 31008, Spain
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GSK Investigational Site
RECRUITINGSantander, 39011, Spain
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GSK Investigational Site
RECRUITINGZaragoza, 50009, Spain
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GSK Investigational Site
RECRUITINGLund, 22185, Sweden
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GSK Investigational Site
RECRUITINGStockholm, SE-118 83, Sweden
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