New hope for stomach and bowel cancers? experimental drug enters human trials

NCT ID NCT06885034

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 04, 2026 · Updated 5 times

Summary

This study tests an experimental drug called GSK5764227, given alone or with other treatments, in 320 people with advanced gastrointestinal cancers that have not responded to prior therapy. The main goal is to see if the drug can shrink tumors and how safe it is. It is an early-stage trial, so results will help determine if larger studies are warranted.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GSK5764227 (an experimental biologic drug)
What this could lead to: If successful, this could point toward a new treatment option for people with advanced gastrointestinal cancers that have stopped responding to prior therapies.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants, so the drug may not work as hoped or could have unexpected side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal neoplasm digestive system neoplasm pancreatic adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROINTESTINAL NEOPLASMS

Contacts and locations

Locations

GSK Investigational Site
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Los Alamitos, California, 90505, United States
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Los Angeles, California, 90089, United States
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Santa Monica, California, 90404, United States
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Whittier, California, 90602, United States
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Aurora, Colorado, 80045, United States
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New York, New York, 10021, United States
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New York, New York, 10065, United States
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Durham, North Carolina, 27710, United States
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Houston, Texas, 77479, United States
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San Antonio, Texas, 78229, United States
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Wenatchee, Washington, 98801, United States
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Madison, Wisconsin, 53792-0001, United States
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Heidelberg, Victoria, 3084, Australia
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Melbourne, Victoria, 3000, Australia
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Bonheiden, 2820, Belgium
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Brussels, 1200, Belgium
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Leuven, 3000, Belgium
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Roeselare, 8800, Belgium
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Porto Alegre, 90850-170, Brazil
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São Paulo, 01246-000, Brazil
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Teresina, 64049-200, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H2X 0C1, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Helsinki, 00029, Finland
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Helsinki, 00180, Finland
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Kuopio, 70210, Finland
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Tampere, 33520, Finland
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Dijon, 21079, France
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Marseille, 13273, France
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Paris, 75010, France
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Paris, 75012, France
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Paris, 75015, France
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Poitiers, 86021, France
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Rennes, 35042, France
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Villejuif, 94805, France
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Bochum, 44791, Germany
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Düsseldorf, 40225, Germany
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Frankfurt, 60488, Germany
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Lübeck, 23562, Germany
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München, 81737, Germany
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Milan, 20133, Italy
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Milan, 20162, Italy
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Pisa, 56126, Italy
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Roma, 00168, Italy
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Aichi, 464-8681, Japan
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Chiba, 277-8577, Japan
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Hokkaido, 060-8648, Japan
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Osaka, 565-0871, Japan
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Tokyo, 104-0045, Japan
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Tokyo, 135-8550, Japan
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Tuxtla Gutiérrez, Chiapas, 29090, Mexico
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Cuernavaca, Morelos, 62448, Mexico
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Mexico City, 03100, Mexico
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Mexico City, 06100, Mexico
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San Pedro Garza García, 66260, Mexico
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Amsterdam, 1066 CX, Netherlands
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Maastricht, 6229 HX, Netherlands
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Rotterdam, 3015 GD, Netherlands
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Utrecht, 3584 CX, Netherlands
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Lrenskog, 1474, Norway
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Oslo, 0407, Norway
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Stavanger, 4011, Norway
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La Villa de Los Santos, Los Santos Province, 6040, Panama
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Punta Pacifica Panama City Panama, Panama
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Brzozów, 36-200, Poland
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Koszalin, 75-581, Poland
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Warsaw, 02-034, Poland
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Seoul, Seoul Teugbyeolsi, 110 744, South Korea
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Seoul, 135-710, South Korea
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Seoul, 138-736, South Korea
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Barcelona, 08041, Spain
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HebrOn, 08035, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Madrid, 28041, Spain
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Pamplona, 31008, Spain
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Santander, 39011, Spain
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Zaragoza, 50009, Spain
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Gothenburg, SE-413 45, Sweden
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Lund, 22185, Sweden
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Stockholm, SE-118 83, Sweden
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Uppsala, 751 85, Sweden
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Manchester, M20 4BX, United Kingdom

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