Can a pill rouse the immune system against pancreatic cancer?

NCT ID NCT04123574

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This early-phase trial is testing whether an experimental oral drug called BXCL701 can change how the immune system responds to pancreatic cancer. The study will enroll people with untreated, locally advanced or metastatic pancreatic cancer who can undergo tumor biopsies before and after treatment. Researchers will measure immune markers in the blood and tumor, and check whether the drug affects tumor growth or cell death. The goal is to see if this approach is worth studying further.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
talabostat mesylate (BXCL701), an oral drug that inhibits dipeptidyl peptidases to modulate the immune system
What this could lead to
If it works, this could point toward a new way to treat pancreatic cancer by harnessing the immune system.
What could go wrong
This is a very early, small pilot study, so it may not show clear benefit or may have side effects. The results may not lead to a larger trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • BioXcel Clinical Research Site

    Boston, Massachusetts, 02215, United States

  • BioXcel Clinical Research Site

    New York, New York, 10021, United States

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