GASTROINTESTINAL NEOPLASMS

This study tests whether a new drug, IDRX-42, works better than the current drug sunitinib for adults with advanced gastrointestinal stromal tumors (GIST) that have spread or can't be removed by surgery and have already been treated with imatinib. About 450 participants will be r…

This study is the first time IDRX-42 is being tested in people. It is for adults with advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tum…

This study looks at adults whose platelet counts stayed low after finishing chemotherapy for gastrointestinal cancers (like stomach, pancreas, or colorectal). Participants get either a standard platelet-boosting drug alone or combined with another medicine (ATRA) for 12 weeks. Th…

This study tests a new medicine called GSK5764227 in people with advanced gastrointestinal cancers that have spread and are not removable by surgery. The goal is to see if the drug can shrink tumors and how safe it is. About 320 adults who have already tried other treatments will…

This early-phase study tests an experimental drug called JNJ-89402638 in people with advanced colorectal or stomach cancer that has spread and not responded to prior treatments. The study will also test the drug combined with bevacizumab (with or without chemotherapy) for colorec…

This study tests a new medicine, PF-08634404, combined with chemotherapy against the standard treatment (bevacizumab plus chemotherapy) in people with colorectal cancer that has spread. About 800 adults who have not had prior treatment for metastatic disease will be randomly assi…

This study tests a new, non-invasive imaging technique that uses light to measure blood flow during gastrointestinal surgery, comparing it to the standard method that uses a dye called indocyanine green. About 200 adults having elective bowel surgery will be randomly assigned to …

This study looks at whether fecal microbiota transplantation (FMT) can reduce or prevent nausea, vomiting, and diarrhea caused by chemotherapy or targeted therapy in people with advanced gastrointestinal cancers. About 90 adults with stage IV cancer who are about to start their 4…

This study tests whether using virtual reality (VR) can reduce severe belly pain in people with digestive tract cancers. 360 participants will be split into three groups: one using skills-based VR, one using distraction VR, and a sham control group. Researchers will track pain, a…

This study collects videos and images from 1,650 adults having routine upper or lower endoscopy (gastroscopy or colonoscopy) to test how well artificial intelligence can spot early gastrointestinal cancers. The goal is to see if AI can help doctors find and identify suspicious gr…

This study follows 8,000 adults who undergo a minimally invasive procedure to remove precancerous or early cancerous growths in the digestive tract. Researchers track how often the removal is complete and safe, and how many people stay cancer-free after one year. The goal is to i…