GASTROINTESTINAL CANCER

This study tests a drug called patritumab deruxtecan in people with advanced gastrointestinal cancers that have spread. The main goals are to see if the drug is safe and how many people's tumors shrink or disappear. About 180 adults with certain types of stomach, bowel, liver, or…

This study is testing several new experimental drugs (RAS(ON) inhibitors) combined with standard chemotherapy or other targeted therapies for people with advanced colorectal or pancreatic cancer. The goal is to see if these combinations are safe and can shrink tumors. About 1,130…

This early-phase study tests a new treatment called GC203 TIL for people with advanced solid tumors (cancers in organs like the breast, lung, or gut) that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to bet…

This study tests the drug atezolizumab in about 200 adults with different incurable solid tumors. Researchers use each person's tumor DNA and RNA to see if their cancer might respond to the drug. Participants receive the same dose every 3 weeks, and the study checks if the geneti…

This early-phase study tests a combination of two drugs, sacituzumab govitecan and capecitabine, in people with advanced gastrointestinal cancers (such as stomach, colon, or pancreatic cancer) that have stopped responding to standard treatments. The main goal is to find a safe an…

This study tests a new treatment for people with certain advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12V. The treatment involves taking a patient's own white blood cells, modifying them in a lab to better recognize…

This study tests a new drug called DR30206 combined with standard treatments for people with advanced or spreading gastrointestinal cancers. The goal is to find safe doses and see if the combination can shrink tumors. About 186 adults aged 18 to 75 will take part in China.

This early-phase trial tests a combination of two targeted drugs, neratinib and fam-trastuzumab deruxtecan (Enhertu), in people with advanced stomach, esophageal, or other gastrointestinal cancers that have a specific marker called HER2. Participants must have already tried at le…

This early-stage study tests a new drug, QXL138AM, for safety in about 100 people with advanced solid tumors (like ovarian, pancreatic, lung, or breast cancer) or multiple myeloma. Participants must have tried other treatments without success. The study will find the right dose a…

This early-stage study tests a new treatment for adults with advanced gastrointestinal cancer that hasn't responded to standard therapies. The treatment combines a drug called XH001 with a personalized vaccine made from the patient's own tumor markers, plus immune cells trained t…

This study tests a new way to care for cancer patients who also have other chronic conditions like diabetes or high blood pressure. It brings together cancer doctors and primary care providers to improve communication and support. The goal is to help patients better manage their …

This study tests whether a dye called CYTALUX™, given before surgery, can help surgeons see cancer tissue in real time using a special camera. It includes 15 adults with stomach, esophagus, or appendix cancer who are already scheduled for surgery. The goal is to improve how compl…

This study looks at whether having a conversation about care goals in the emergency department can improve quality of life for people with advanced lung or gastrointestinal cancer. It involves 200 adults who are at least 18, have advanced cancer, and have certain severe symptoms.…

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps immune cells attack…

This study looks at whether different amounts of aerobic exercise (like walking or cycling) can help people with stomach, esophageal, or colorectal cancer better tolerate chemotherapy. About 216 adults who are about to start chemo will be assigned to different exercise levels. Th…

This study looks at sleep habits in people with gastrointestinal cancer and their sleep partners (like a spouse). It tests two different programs to help improve sleep quality and reduce insomnia. About 152 patient-partner pairs will join, and the study tracks sleep changes over …

This study tests a program called BOLSTER designed to support people with advanced gynecologic or gastrointestinal cancers and their caregivers. Participants will receive extra help managing complex care needs like ostomies or feeding tubes. The goal is to see if the program impr…

This study is testing whether a remote resistance training program is practical and safe for 100 adults with advanced upper gastrointestinal cancer who are receiving chemotherapy. Participants will do guided strength exercises from home using video calls. The goal is to see if pe…

This early-phase study tests whether an artificial intelligence platform can personalize cancer treatment for people with solid tumors (like breast or gastrointestinal cancer). Researchers will use a patient's own tumor sample to pick the best drug combination, then an AI system …

This study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemotherapy drugs. Participants will give blood samples a…

This study follows 180 adults with gastrointestinal or sarcoma cancers who are receiving standard treatments like radiation. Researchers will monitor how long patients live without cancer returning and track any side effects. The goal is to learn how newer treatments are affectin…

This early-phase study tests whether a special dye called pafolacianine (CYTALUX) can make cancer cells glow during surgery for gastrointestinal cancers that have spread inside the abdomen. About 10 adults will receive the dye before surgery, and surgeons will use a special camer…

This study collects blood and tumor samples from 550 adults with gastrointestinal cancers (throat, stomach, gallbladder, liver, pancreas, or colon) to understand how the immune system fights the cancer. Participants give blood samples at the start, after 2 and 4 months, and at th…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at curing their disease. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA that might remain after treatment. The goal is to lea…

This study looks at how common muscle loss (sarcopenia) is in people with gastrointestinal cancer. Researchers will use a simple questionnaire to screen patients before and during treatment. Those at risk will get extra nutritional support. The goal is to catch muscle loss early …

This study looks at whether a comprehensive genetic test (microarray PGx) can find more drug-gene interactions than the standard single-gene test in people with cancer. Researchers will enroll 120 adults with gastrointestinal cancer who are about to receive chemotherapy. The goal…

This study looks at why cancer patients feel very tired during chemotherapy and radiation. Researchers will collect blood and stool samples from 125 adults with different cancers before, during, and after treatment. They aim to find links between fatigue and changes in genes and …

This study is testing whether a special type of PET scan (PSMA-PET) can find and monitor certain digestive system cancers, like liver, colon, and pancreatic cancers. Researchers will compare the scan results with standard imaging and tissue samples from 46 newly diagnosed patient…

This study looks at frailty—symptoms like weight loss, weakness, and slow walking—in 100 gastrointestinal cancer patients from rural and urban areas before they have major surgery. Researchers will use a survey, blood sample, and medical records to see if frailty affects recovery…

This study collects blood, tumor, and other tissue samples from up to 1,250 people with head and neck, lung, or gastrointestinal cancers. Researchers will analyze these samples to learn how different cancer treatments affect the immune system, identify who might develop side effe…

This study looks at how many people with gastrointestinal cancer are at risk for sarcopenia, a condition where muscle mass and strength are lost. Sarcopenia can make cancer treatment harder and lower quality of life. Researchers will use a simple questionnaire (SARC-F) to screen …

This study aims to see if lab-grown tumor models can predict how well heated chemotherapy (HIPEC) works during surgery for cancers that have spread to the abdomen. About 60 adults whose tumors cannot be fully removed safely will take part. Researchers will compare tumor responses…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to the cancer care team helps people aged 70 and older with gastrointestinal cancers. Researchers want to see if this approach is practical and if it reduces unplanned hospital v…

This study tests whether a patient navigator, text message check-ins, and an educational video can help more Black, Latinx, and older adults (70+) with advanced gastrointestinal, blood, or lung cancers get the genomic testing needed to join precision cancer trials. About 210 part…