GASTROINTESTINAL CANCER

This study tests a new medicine, raludotatug deruxtecan, in 160 people with advanced gastrointestinal cancers like pancreatic, bile duct, colorectal, stomach, or gastroesophageal junction cancer. The drug is designed to attach to cancer cells and deliver a treatment that destroys…

This study tests whether taking postbiotic supplements after colon cancer surgery can help restore healthy gut bacteria. The surgery and antibiotics often disrupt the natural balance of bacteria in the gut. The trial will compare changes in gut bacteria diversity between people w…

This phase 2 study tests whether avatrombopag, a drug that boosts platelet production, can safely and effectively treat persistent low platelet counts caused by chemotherapy in people with gastrointestinal cancers. About 60 adults will receive either avatrombopag or a placebo. Th…

This early-phase trial tests a treatment for adults with certain advanced solid tumors (like colorectal, lung, or breast cancer) that have spread and stopped responding to standard therapy. The approach uses a person's own white blood cells, which are genetically modified in a la…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at higher risk of coming back after radiation alone. About 134 adults with cancers like melanoma, lung, breast, or colorectal cance…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. About 20 adults with various CEA-positive cancers will receive the injection and have scans over two days. The goal is to see if this method can dete…

This study tests whether a chatbot combined with continuous activity monitoring via a smartphone can help detect and manage symptoms early in people undergoing chemotherapy and radiation for lung, gastrointestinal, or head and neck cancers. The goal is to reduce unplanned hospita…

This early-stage study tests whether a carefully guided psilocybin (magic mushroom) session can help reduce depression and anxiety in people with advanced, incurable gastrointestinal cancers. The study enrolls 24 adults aged 19-85 who live near Omaha, NE, and have a family member…

This study looks back at medical records of 72 American Indian adults with cancers like lung, melanoma, and kidney who received immunotherapy. Researchers compare their outcomes, such as cancer progression and side effects, to those of White patients. The goal is to spot any diff…

This study gathers information from 100 adults with breast, lung, gastrointestinal cancer, or multiple myeloma. Participants complete weekly online surveys about their symptoms and treatment experience for at least 12 weeks. The goal is to learn how symptoms change over time, not…

This study looks at whether giving doctors information about a patient's genes can help them personalize chemotherapy doses and reduce severe side effects. About 860 adults with certain cancers (like breast, gastrointestinal, or head and neck) will be randomly assigned to have th…

This study collects white blood cells and tumor cells from up to 7,000 cancer patients and healthy volunteers. The cells are used in the lab to grow large numbers of immune cells that may be given back to patients in future experimental treatments. No direct treatment is provided…

This study aimed to understand sleep problems in people with gastrointestinal (GI) cancers before and after surgery. Researchers planned to ask patients to fill out a simple sleep questionnaire each day they were in the hospital. The goal was to track how well patients slept and …

This study looks at whether a new training program for nurses, called PACT, helps them provide better care that includes the patient's family. Nurses and family caregivers of people with advanced gastrointestinal cancer will take part. The goal is to see if the training improves …

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. About 1,200 adults aged 1…