GASTROINTESTINAL CANCER

This study tested whether adding an experimental drug called TJ004309 to an existing immunotherapy (atezolizumab) could help control advanced cancers that have stopped responding to standard treatments. It involved 25 patients with specific types of advanced solid tumors, includi…

This first-in-human study tested a new drug called Cabotamig in 33 adults with advanced gastrointestinal cancers that had stopped responding to standard treatments. The main goals were to check the drug's safety, see how the body processes it, and look for early signs that it mig…

This early-phase trial tested a new cell therapy for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Researchers collected a patient's own immune cells from a tumor, used CRISPR gene editing to remove a molecular 'brake' (CISH), a…

This early-phase trial tested a new personalized therapy for advanced gastrointestinal and other cancers driven by a specific genetic flaw called RAS G12D. Researchers collected a patient's own immune cells, genetically modified them in a lab to recognize and attack cancer cells …

This small, completed study tested whether ultrasound could be a better way to detect nerve damage caused by the chemotherapy drug oxaliplatin. Researchers compared ultrasound images of leg nerves from 20 patients with gastrointestinal cancer to data from healthy people. The goal…

This study tested whether adding oral nutrition supplements to standard chemotherapy could help patients with gastrointestinal cancer. Researchers wanted to see if the extra nutrition would help patients better tolerate chemotherapy, improve their body weight and strength, and en…

This study tested whether adding a specialized support team (palliative care) to work alongside surgeons improves the experience for patients undergoing major stomach, pancreas, or liver cancer surgery and their family caregivers. It compared the standard surgeon-led care to a ne…

This study tested a support program called BOLSTER for people with gynecologic or gastrointestinal cancers and their caregivers. The goal was to help them better manage the transition home after a hospital stay by providing education, skills training, and symptom support. The res…

This study tested a new approach to managing side effects during cancer radiation treatment. It involved 104 patients with lung or gastrointestinal cancers. The goal was to see if having patients directly report their symptoms to their doctors each week led to better detection an…

This study tested a remote support program to help people with gastrointestinal cancer eat well during and after treatment. It involved 10 patients who had recently undergone major surgery. The goal was to see if the program was practical and if patients found it helpful, using t…

This study aimed to understand how a common chemotherapy drug, 5-Fluorouracil (5-FU), affects small blood vessels, which may explain its known link to heart problems. Researchers compared blood flow in the skin of 62 people across four groups: current 5-FU patients, patients on o…

This study aimed to understand why cancer patients with weight loss experience muscle weakness and fatigue. Researchers examined muscle tissue from 51 patients with gastrointestinal cancer, comparing those with significant weight loss to those without. The goal was to learn how c…

This study aimed to find the best ways to encourage doctors and patients to use a genetic test before starting certain chemotherapy drugs. The test checks for a gene change that can cause severe, sometimes fatal, side effects. Researchers gathered feedback from doctors, patients,…