Can walking during chemo reduce side effects? new study aims to find the best dose

NCT ID NCT05789485

Recruiting now Symptom relief Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing three different amounts of treadmill walking (90, 150, or 300 minutes per week) in people receiving chemotherapy for colorectal or stomach cancers. The goal is to find a safe and practical exercise level that helps patients complete their full chemotherapy plan with fewer side effects. The study will track how well participants tolerate treatment and whether exercise improves their overall health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: structured treadmill walking
What this could lead to: If successful, this could establish a recommended amount of aerobic exercise to help patients tolerate chemotherapy better and reduce side effects.
What could go wrong: This is a Phase 2 trial with 216 participants, so results are preliminary. Exercise may not benefit everyone, and some patients may find the walking schedule difficult to maintain.

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Conditions

The condition(s) this trial relates to.

colorectal cancer digestive system cancer digestive system neoplasm gastroesophageal cancer Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROINTESTINAL CANCER

Contacts and locations

Locations

Hartford Healthcare Alliance (Data Collection Only)
RECRUITING

Hartford, Connecticut, 06102, United States
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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