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Which test is best for colon cancer screening in High-Risk families?

NCT ID NCT02738359

Completed Diagnosis Sponsor: Hôpital Edouard Herriot Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at three screening methods—colonoscopy, colon capsule endoscopy, and a fecal immunochemical test (FIT)—to detect colorectal cancer or advanced growths in people aged 45 and older who have a first-degree relative with colorectal cancer. The goal was to see if the simpler tests (capsule or FIT) are as good as colonoscopy. The study enrolled 84 participants and compared how many cancers or advanced polyps each method found.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could show that simpler, less invasive tests like colon capsule or fecal tests are as effective as colonoscopy for screening high-risk relatives.
What could go wrong
This is a small, completed study with only 84 participants, so results may not apply to larger populations. The non-inferiority margin is narrow, and differences between tests may still be uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm colorectal cancer rectal cancer rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLON CANCER RECTUM CANCER

Contacts and locations

Locations

  • CH d'Avignon

    Avignon, Provence-Alpes-Côte d'Azur Region, 84000, France

  • CHI de Créteil

    Créteil, Île-de-France Region, 94000, France

  • CHU de Besançon - Hôpital Minjoz

    Besançon, Franche-Comté, 25030, France

  • CHU de Bordeaux - Hôpital Haut-Lévêque

    Pessac, Aquitaine, 33604, France

  • CHU de Brest - Hôpital de la Cavale Blanche

    Brest, Brittany Region, 29200, France

  • CHU de Dijon

    Dijon, Bourgogne-Franche-Comté, 21000, France

  • CHU de Limoges - Hôpital Dupuytren

    Limoges, Limousin, 87000, France

  • CHU de Nantes - Hôpital de l'Hôtel-Dieu

    Nantes, Pays de la Loire Region, 44000, France

  • CHU de Nice - Hôpital Archet II

    Nice, Provence-Alpes-Côte d'Azure, 06200, France

  • CHU de Rouen - Hôpital Charles Nicolle

    Rouen, Normandy, 16000, France

  • CHU de Saint-Etienne - Hôpital nord

    Saint-Priest-en-Jarez, Auvergne-Rhône-Alpes, 42270, France

  • CHU de Toulouse

    Toulouse, Midi-Pyrénées, 31059, France

  • Hôpital Avicenne - AP-HP

    Bobigny, Île-de-France Region, 93000, France

  • Hôpital Cochin - AP-HP

    Paris, Île-de-France Region, 75014, France

  • Hôpital Edouard Herriot - Hospices civils de Lyon

    Lyon, Auvergne-Rhône-Alpes, 69000, France

  • Hôpital Saint-Antoine - Assistance publique-Hôpitaux de Paris

    Paris, Île-de-France Region, 75012, France

  • Hôpital de la Timone - AP-HM

    Marseille, Provence-Alpes-Côte d'Azur Region, 13385, France

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