Smart immune cells take aim at Hard-to-Treat cancers

NCT ID NCT06051695

Recruiting now Disease control Sponsor: A2 Biotherapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovarian, and mesothelioma, that have not responded to other treatments. The study has two phases: first to find a safe dose, and second to see if the treatment shrinks tumors.

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Conditions

The condition(s) this trial relates to.

cancer colon carcinoma colonic neoplasm colorectal adenocarcinoma colorectal cancer colorectal carcinoma colorectal neoplasm lung cancer lung neoplasm malignant mesothelioma malignant pancreatic neoplasm mesothelioma Mesothelioma, Malignant neoplasm non-small cell lung carcinoma non-small cell squamous lung carcinoma ovarian cancer ovarian neoplasm pancreatic neoplasm rectal cancer rectal neoplasm Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER COLON CANCER COLORECTAL ADENOCARCINOMA COLORECTAL CANCER CRC LUNG CANCER MESOM MESOTHELIOMA MESOTHELIOMA, MALIGNANT NON-SMALL CELL LUNG CANCER NON-SMALL CELL SQUAMOUS LUNG CANCER NSCLC NSCLC, RECURRENT OVARIAN CANCER OVARIAN NEOPLASMS OVARY CANCER PANCREAS CANCER PANCREATIC NEOPLASM RECTAL CANCER SOLID TUMOR, ADULT

Contacts and locations

Locations

Banner Health
RECRUITING

Gilbert, Arizona, 85234, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33606, United States
NYU Langone Medical Center
RECRUITING

New York, New York, 10016, United States
Stanford University
RECRUITING

Stanford, California, 94305, United States
The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
UCLA Medical Center
RECRUITING

Los Angeles, California, 90404, United States
UCSD Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

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