OVARIAN NEOPLASMS

This trial tests a new drug, UCB4594, designed to help the immune system attack cancer cells by targeting a protein called HLA-G found on many tumors. It is for people with advanced solid cancers that have not responded to standard treatments. The study aims to find the safest do…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment involves collecting a patient's own immune cells, modifying them in a lab to better re…

This study offers ongoing access to the drug niraparib for people with ovarian or breast cancer who have already completed a previous niraparib trial and are still benefiting from the treatment. About 30 participants will continue taking niraparib to monitor long-term safety and …

This study tests a new targeted therapy, sacituzumab tirumotecan (Sac-TMT), as maintenance treatment for people with advanced ovarian cancer that is not HRD positive. After initial chemotherapy, participants will receive Sac-TMT with or without bevacizumab, or standard care. The …

This study tests a new drug called LY4337713, which delivers radiation directly to cancer cells that have a specific protein (FAP). It is for adults with advanced or spread-out cancers like pancreatic, breast, ovarian, colorectal, esophageal, stomach, or bile duct cancer. The mai…

This early-stage study tests a new drug, PF-08046054/SGN-PDL1V, in people with advanced solid tumors that have spread or can't be removed. The drug is given alone or with pembrolizumab to see if it's safe and what side effects occur. About 714 participants with cancers like lung,…

This study tests a new drug, BMS-986340, alone or with other cancer treatments in people with advanced solid tumors that have not responded to standard therapy. The main goal is to find safe doses and check for side effects. About 949 adults with various cancers like lung, breast…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that have lost a specific marker on their cells. The treatment uses the patient's own immune cells, modified to target cancer cells while protecti…

This early-phase study tests a new drug called DM002 in 160 people with advanced solid tumors (ovarian, prostate, endometrial, colorectal, or other solid cancers). The study has two parts: first, finding a safe dose by testing low to higher doses in small groups; second, giving t…

This study tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with other rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various tumor types will receive the drug com…

This study tests whether a drug that boosts the immune system (dostarlimab), alone or with a drug that blocks blood vessel growth (bevacizumab), works better than standard chemotherapy for women whose gynecological clear cell cancer has come back. About 198 women will be randomly…

This study tests an experimental drug called LY3537982 in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drug is safe and shrinks tumors. About 540 adults with lung, colorectal, endometrial, ovarian, pancreatic, or bile duct c…

This early-phase study tests an experimental pill, NKT3964, designed to break down a protein (CDK2) that helps cancer cells grow. About 150 adults with advanced or metastatic solid tumors (including ovarian, endometrial, breast, gastric, and lung cancers) that have stopped respon…

This early-stage trial tests a drug called sigvotatug vedotin, alone or with other medicines, in people with advanced solid tumors like lung, head and neck, or breast cancer. The main goal is to check safety and find the right dose. About 1,000 participants will join this study t…

This study tests two drugs, vemurafenib and cobimetinib, already approved for melanoma, in adults with other rare cancers that have a specific BRAF V600 gene change. About 30 people will take the drugs to see if their tumors shrink or stop growing. The goal is to find new uses fo…

This study tests a new drug, Sofetabart Mipitecan, for people with ovarian, fallopian tube, or peritoneal cancer. Part A includes those whose cancer no longer responds to platinum chemotherapy, and Part B includes those whose cancer still responds. The goal is to see if the new d…

This study tests a new drug called LY4170156 in people with advanced solid tumors, such as ovarian, lung, and breast cancers. The drug is designed to target and kill cancer cells while sparing healthy ones. The trial has two parts: first to find the safest dose, then to see how w…

This study tests a new ultrasound method called ultrasound microvessel imaging (UMI) to see if it can better detect blood flow in ovarian growths. Current tools often miss early signs of cancer. About 40 women scheduled for surgery for ovarian lesions will get this extra scan. Do…

This study aims to develop a test that finds ovarian cancer earlier by looking at DNA from a uterine wash and proteins in the blood. Researchers will collect samples from 250 women before surgery for a suspected ovarian mass or as a preventive measure. The goal is to see if these…

This study tests a less invasive method called sentinel lymph node biopsy to see if it can safely replace the standard removal of many lymph nodes in women with early-stage ovarian cancer. The goal is to find cancer spread with fewer side effects, shorter hospital stays, and fast…

This study tests a tool called CASI that helps ovarian cancer patients, their caregivers, and doctors set a shared plan for each doctor visit. The goal is to make conversations more focused and helpful. About 112 people with advanced ovarian cancer and their caregivers will take …

This study aims to understand how ovarian cancer affects the immune system, especially in the bone marrow and blood. Researchers will compare immune cells from 90 women with ovarian cancer to those without cancer. The goal is to find new ways to boost the immune system to fight t…

This observational study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for possible futur…