New study gathers key materials to create personalized cell therapies for tough cancers

NCT ID NCT04981119

Recruiting now Knowledge-focused Sponsor: A2 Biotherapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential future CAR T-cell therapy. No treatment is given in this study—it only gathers information and materials for later research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help create personalized CAR T-cell therapies for hard-to-treat solid tumors like colorectal, lung, and pancreatic cancers.
What could go wrong: This is an early, observational study that does not test any treatment. It only collects samples for future research, so there is no direct benefit to participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer colorectal cancer colorectal carcinoma colorectal neoplasm head and neck squamous cell carcinoma kidney cancer malignant mesothelioma malignant pancreatic neoplasm malignant pleural mesothelioma mesothelioma Mesothelioma, Malignant neoplasm non-small cell lung carcinoma ovarian cancer ovarian carcinoma ovarian neoplasm pancreatic neoplasm pleural mesothelioma renal cell carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER COLORECTAL CANCER CRC HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) MESOTHELIOMA MESOTHELIOMA, MALIGNANT MESOTHELIOMA; LUNG NON-SMALL CELL LUNG CANCER NSCLC OVARIAN CANCER OVARIAN CARCINOMA OVARIAN NEOPLASMS PANCREAS CANCER PANCREATIC CANCER RENAL CELL CARCINOMA (KIDNEY CANCER) SOLID TUMOR, ADULT TRIPLE-NEGATIVE BREAST CANCER (TNBC)

Contacts and locations

Locations

Banner Health
RECRUITING

Gilbert, Arizona, 85234, United States
City of Hope
COMPLETED

Duarte, California, 90101, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
MD Anderson Cancer Center
COMPLETED

Houston, Texas, 77030, United States
Massachusetts General Hospital/Dana Farber Cancer Institute
COMPLETED

Boston, Massachusetts, 02114, United States
Mayo Clinic Hospital
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33136, United States
NYU Langone Medical Center
RECRUITING

New York, New York, 10016, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
UCLA Medical Center
RECRUITING

Santa Monica, California, 90404, United States
University of California San Diego
RECRUITING

La Jolla, California, 92093, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

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