New hope for Hard-to-Treat cancers: experimental drug enters human trials

NCT ID NCT05208762

Recruiting now Disease control Sponsor: Seagen, a wholly owned subsidiary of Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This early-stage study tests a new drug called PF-08046054/SGN-PDL1V, alone or with another drug (pembrolizumab), in people with advanced solid tumors like lung, head and neck, esophageal, breast, stomach, endometrial, pancreatic, or liver cancer. The main goals are to find safe doses and understand side effects. About 714 participants will take part across five parts of the study.

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Conditions

The condition(s) this trial relates to.

endometrial cancer endometrium neoplasm esophageal squamous cell carcinoma gastric cancer gastric neoplasm head and neck squamous cell carcinoma hepatocellular carcinoma malignant pancreatic neoplasm melanoma non-small cell lung carcinoma ovarian neoplasm pancreatic adenocarcinoma Squamous Cell Carcinoma of Head and Neck triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG ENDOMETRIAL CANCER ESOPHAGEAL SQUAMOUS CELL CARCINOMA GASTRIC CANCER HEPATOCELLULAR CARCINOMA MELANOMA OVARIAN NEOPLASMS PANCREATIC ADENOCARCINOMA SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK TRIPLE NEGATIVE BREAST NEOPLASMS

Contacts and locations

Locations

Apotheke-Zytostatika Studien Charite- Universitatsmedizin Berlin Campus Virchow Klinkum
RECRUITING

Berlin, 13353, Germany
Azienda Ospedaliera Universitaria Integrata Verona - Policlinico G.B Rossi
RECRUITING

Verona, Veneto, 37134, Italy
Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China
Beijing Friendship Hospital, Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100050, China
Beijing Friendship hospital, Capital Medical University
RECRUITING

Beijing, China
CETIR Viladomat
RECRUITING

Barcelona, Other, 08029, Spain
Centro Ricerche Cliniche di Verona s.r.l. c/o Policlinico G.B Rossi
RECRUITING

Verona, Other, 37134, Italy
Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States
Charite Comprehensive Cancer Center
RECRUITING

Berlin, 10117, Germany
Charite Universitatsmedizin Berlin
RECRUITING

Berlin, 12200, Germany
Clinique Ambroise Pare
RECRUITING

Neuilly-sur-Seine, 92200, France
Diagnostic Centre
RECRUITING

London, Others, W1G 7AF, United Kingdom
Divisione di Sviluppo di Nuovi Farmaci per Terapie Innovative lstituto Europeo di Oncologia
RECRUITING

Milan, Milan, 20141, Italy
Gustave Roussy Institute
RECRUITING

Villejuif, 94805, France
Gustave Roussy Institute - Service pharmacie
RECRUITING

Villejuif, 94805, France
Hospital Duran I Reynals-Institut Català d'Oncologia L'Hospitalet (ICO L'Hospitalet)
RECRUITING

Barcelona, Other, 08908, Spain
Hospital Quiron Salud Barcelona
RECRUITING

Barcelona, 08023, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hôpital Saint André - CHU Bordeaux
RECRUITING

Bordeaux, 33075, France
Institut Curie
RECRUITING

Paris, 75005, France
Institut Jules Bordet
RECRUITING

Anderlecht, 1070, Belgium
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Karmanos Cancer Institute
RECRUITING

Farmington Hills, Michigan, 48334, United States
McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
NEXT Oncology Barcelona - IOB - Hospital Quironsalud Barcelona
RECRUITING

Barcelona, 08023, Spain
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
NEXT Virginia, LLC
RECRUITING

San Antonio, Texas, 78229, United States
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
Pharmacy: Royal Marsden Hospital
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
Radiology
RECRUITING

London, W1G 8PP, United Kingdom
Royal Marsden Hospital
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
START Madrid - CIOCC - Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
START Mountain Region
RECRUITING

West Valley City, Utah, 84119, United States
Sarah Cannon Research Institute
RECRUITING

London, W1G 6AD, United Kingdom
Shanghai East Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200123, China
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, Shizuoka, 411-8777, Japan
South Texas Accelerated Research Therapeutics, LLC
RECRUITING

San Antonio, Texas, 78229, United States
The Harley Street Clinic (THSC)
RECRUITING

London, Other, W1G 8BJ, United Kingdom
The Netherlands Cancer Institute
RECRUITING

Amsterdam, 1066 CX, Netherlands
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services
RECRUITING

Houston, Texas, 77030, United States
UC Irvine Health - Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States
UOC Oncologia - IRCCS Azienda Ospedaliero Universitaria Bologna
RECRUITING

Bologna, 40138, Italy
UT Southwestern - Simmons Cancer Center - Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
UT Southwestern - Simmons Cancer Center - Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern Medical Center - Redbird
RECRUITING

Dallas, Texas, 75237, United States
Univ. of TX Southwestern Medical Center - Zale Lipshy University Hospital
RECRUITING

Dallas, Texas, 75390, United States
University Health Network
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
University Health Network, Princess Margaret Hospital
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University Of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35249, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of Alabama at Birmingham, IDS Pharmacy
RECRUITING

Birmingham, Alabama, 35249, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of California, Davis Medical Center
RECRUITING

Sacramento, California, 95817, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Texas Southwestern Medical Center - Simmons Cancer Center
RECRUITING

Dallas, Texas, 75235, United States
University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital
RECRUITING

Dallas, Texas, 75390, United States
lnstitut Curie Pharmacy
RECRUITING

Paris, 75005, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.