SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Clinical trials for SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK explained in plain language.
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New cancer vaccine Modi-1 enters human trials for four tumor types
⭐️ VACCINE ⭐️ Recruiting nowThis study tests a new vaccine called Modi-1, designed to train the immune system to attack cancer cells. It is given as a tiny shot into the skin using a special microneedle device. The trial includes 168 people with advanced triple-negative breast cancer, head and neck cancer, …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1, PHASE2 • Sponsor: Scancell Ltd • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 26, 2026 18:32 UTC
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New drug AB821 enters first human tests for advanced melanoma
Disease control Recruiting nowThis early-stage trial is testing a new drug called AB821 in 50 adults with advanced melanoma or other solid tumors that respond to immune therapies. The main goal is to check safety and find the right dose. Participants receive AB821 by IV every 2 or 3 weeks for up to two years.
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Yale University • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New vaccine could help throat cancer patients avoid radiation
Disease control Recruiting nowThis phase 2 trial tests whether adding an experimental vaccine (PRGN-2009) to standard chemotherapy can improve outcomes for people with newly diagnosed HPV-related throat cancer, potentially allowing them to skip radiation. About 70 adults will receive either chemo alone or che…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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New smart drug targets tough cancers in first human trial
Disease control Recruiting nowThis early-stage trial tests a new drug called M7437 in people with advanced solid tumors that have not responded to standard treatments. M7437 is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells that have a specific marker (Ly6E). The study ai…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: EMD Serono Research & Development Institute, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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New drug targets Hard-to-Treat cancers in large trial
Disease control Recruiting nowThis phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Daiichi Sankyo • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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New nanobody therapy aims to unleash killer cells on hard-to-treat cancers
Disease control Recruiting nowThis early-phase trial tests an experimental drug called GTB-5550 in adults with advanced solid tumors that have stopped responding to standard treatments. The drug is a nanobody designed to bridge natural killer cells to cancer cells, helping the immune system attack the tumor. …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New hope for Hard-to-Treat cancers: experimental drug enters human trials
Disease control Recruiting nowThis early-stage study tests a new drug called PF-08046054/SGN-PDL1V, alone or with another drug (pembrolizumab), in people with advanced solid tumors like lung, head and neck, esophageal, breast, stomach, endometrial, pancreatic, or liver cancer. The main goals are to find safe …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Seagen, a wholly owned subsidiary of Pfizer • Aim: Disease control
Last updated Jun 27, 2026 12:10 UTC
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New drug duo aims to shrink head and neck tumors before surgery
Disease control Recruiting nowThis phase 2 trial tests whether giving two drugs—ficerafusp alfa and pembrolizumab (Keytruda)—before surgery can shrink tumors in people with advanced head and neck cancer. About 32 participants with resectable, PD-L1-positive squamous cell carcinoma will receive the combination…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New drug duo targets tough cancers in early trial
Disease control Recruiting nowThis study tests a combination of two drugs, MCLA-129 and ensartinib, in people with advanced solid tumors that cannot be cured. The drugs work by blocking certain proteins that help cancer grow. The trial has two phases: first to find the safest dose, then to see if the combo sh…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1, PHASE2 • Sponsor: Betta Pharmaceuticals Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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New liposomal drug takes on advanced cancers
Disease control Recruiting nowThis study tests an experimental drug called SMP-3124LP, which is a liposomal (fat-encapsulated) version of a cancer-fighting compound. It is for adults with advanced solid tumors that have not responded to standard treatments. The trial has two parts: first, finding the safest d…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1, PHASE2 • Sponsor: Sumitomo Pharma America, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New injection fights head and neck cancer from the inside
Disease control Recruiting nowThis early-stage trial tests a new treatment called VLPONC-01, which is injected directly into head and neck tumors. It delivers a substance (IL-12) that may help the immune system attack the cancer. Some participants will also receive the immunotherapy drug pembrolizumab. The ma…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: VLP Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Glow-in-the-Dark dye helps surgeons spot hidden cancer
Diagnosis Recruiting nowThis study tests whether a dye called panitumumab-IRDye800 can make head and neck cancer cells glow during surgery, helping surgeons see and remove all cancer while sparing healthy tissue. About 25 adults with head and neck cancer scheduled for surgery will receive the dye before…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: University of Alabama at Birmingham • Aim: Diagnosis
Last updated Jun 27, 2026 08:07 UTC
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Cholesterol drug may shield ears from chemo damage
Symptom relief Recruiting nowThis study tests whether atorvastatin, a widely used cholesterol medication, can reduce hearing loss caused by cisplatin chemotherapy in people with head and neck cancer. About 224 adults will be randomly assigned to take atorvastatin or a placebo daily during and for three month…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD) • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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New daily adaptive radiotherapy aims to spare saliva glands in head and neck cancer patients
Symptom relief Recruiting nowThis phase II trial tests whether daily adaptive radiotherapy (DART) can better protect the submandibular glands during head and neck cancer treatment compared to standard image-guided radiation. About 50 participants will be randomly assigned to receive either standard or adapti…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: NA • Sponsor: University Health Network, Toronto • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Smart radiation aims to cut severe mouth sores in head and neck cancer
Symptom relief Recruiting nowThis study compares standard radiation therapy to a newer method called dose painting for people with head and neck cancer. The goal is to see if dose painting causes fewer severe mouth ulcers one year after treatment. About 100 participants will be randomly assigned to receive e…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: NA • Sponsor: Oslo University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Diet and exercise may ease cancer treatment side effects
Symptom relief Recruiting nowThis study tests whether a 20-week program of nutrition counseling, home-based exercise, and wellness education can reduce side effects and improve quality of life in 30 adults with head and neck cancer undergoing chemoradiation. The program includes weekly group sessions with a …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: NA • Sponsor: Renown Health • Aim: Symptom relief
Last updated Jun 26, 2026 15:21 UTC
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Scientists hunt for blood markers to unmask hidden aggressive tumors
Knowledge-focused Recruiting nowThis study collects blood and tumor tissue samples from people with head and neck or lung cancers to find biological markers that indicate low oxygen levels within tumors. Low-oxygen tumors tend to be more aggressive and resistant to standard treatments like radiation and chemoth…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jul 01, 2026 23:00 UTC
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New imaging study aims to sharpen radiotherapy for head and neck cancer
Knowledge-focused Recruiting nowThis study is testing whether advanced PET/MR imaging can help doctors personalize radiotherapy for head and neck cancer. Researchers will scan 390 patients before, during, and after treatment to see if imaging details can predict survival and response. The goal is to improve out…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Blood test could predict cancer return after surgery
Knowledge-focused Recruiting nowThis study looks at a blood test that measures tiny bits of tumor DNA floating in the blood. Researchers will enroll 50 adults with head and neck cancer who are planning surgery. They want to see how these DNA levels change after surgery and whether they can help predict if the c…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC