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New cancer vaccine Modi-1 enters human trials for four tumor types

NCT ID NCT05329532

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Scancell Ltd Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests a new vaccine called Modi-1, designed to train the immune system to attack cancer cells. It is given as a tiny shot into the skin using a special microneedle device. The trial includes 168 people with advanced triple-negative breast cancer, head and neck cancer, ovarian cancer, or kidney cancer. Some participants will receive the vaccine alone, and others will get it together with standard immune-boosting drugs like pembrolizumab or nivolumab. The main goals are to check safety and see if the vaccine triggers an immune response against the cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Modi-1 moditope vaccine (given with a microneedle device, sometimes combined with pembrolizumab or nivolumab)

What this could lead to

If successful, this could point toward a new vaccine-based treatment that helps the immune system fight several types of advanced cancer.

What could go wrong

This is an early phase 1/2 trial, so safety and effectiveness are not yet proven. The vaccine may not work for all cancer types, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

childhood kidney cell carcinoma head and neck squamous cell carcinoma ovarian serous adenocarcinoma renal cell carcinoma Squamous Cell Carcinoma of Head and Neck triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH GRADE OVARIAN SEROUS ADENOCARCINOMA RENAL CELL CANCER SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Addenbrooke's Hospital, Cambridge University Hospitals

    RECRUITING

    Cambridge, United Kingdom

    Contact Phone: •••-•••-••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Belfast City Hospital

    RECRUITING

    Belfast, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Brighton and Sussex University Hospital

    ACTIVE_NOT_RECRUITING

    Brighton, Default, United Kingdom

  • Christie NHS Foundation Trust

    RECRUITING

    Manchester, Default, United Kingdom

    Contact Email: •••••@•••••

  • Edinburgh Cancer Centre (NHS Lothian)

    RECRUITING

    Edinburgh, Default, United Kingdom

    Contact Email: •••••@•••••

  • Imperial College Healthcare NHS Trust

    ACTIVE_NOT_RECRUITING

    London, Default, United Kingdom

  • Lancashire Teaching Hospitals NHS Foundation Trust

    RECRUITING

    Preston, Default, United Kingdom

    Contact Email: •••••@•••••

  • Mount Vernon

    RECRUITING

    London, Default, United Kingdom

    Contact Email: •••••@•••••

  • Nottingham University Hospitals Cancer Centre

    RECRUITING

    Nottingham, Default, United Kingdom

    Contact Email: •••••@•••••

  • Royal Surrey NHS Foundation

    RECRUITING

    Guildford, Default, United Kingdom

    Contact Email: •••••@•••••

  • Sheffield Teaching Hospital NHS Foundation Trust

    RECRUITING

    Sheffield, Default, United Kingdom

    Contact Email: •••••@•••••

  • The Clatterbridge Cancer Centre NHS Foundation Trust

    RECRUITING

    Liverpool, CH63 4JY, United Kingdom

    Contact Email: •••••@•••••

  • The Royal Marsden NHS Foundation Trust

    NOT_YET_RECRUITING

    Sutton, Default, United Kingdom

    Contact Email: •••••@•••••

  • Torbay and South Devon NHS Foundation Trust

    RECRUITING

    Torquay, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University College London Hospital NHS Foundation Trust

    RECRUITING

    London, Default, United Kingdom

    Contact Email: •••••@•••••

  • Velindre Cancer Centre

    RECRUITING

    Cardiff, Default, United Kingdom

    Contact Email: •••••@•••••