SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Clinical trials for SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK explained in plain language.
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New drug duo tested to fight spreading cancers
Disease control CompletedThis study tested whether combining two existing cancer drugs, brentuximab vedotin and pembrolizumab, could help treat several types of advanced cancer that had spread to other parts of the body. It involved 161 people with metastatic melanoma, non-small cell lung cancer, or head…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Seagen, a wholly owned subsidiary of Pfizer • Aim: Disease control
Last updated Apr 01, 2026 14:43 UTC
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First human trial tests 'Supercharged' donor cells against tough head & neck cancers
Disease control CompletedThis early-stage study tested the safety of a new combination treatment for advanced head and neck cancer. It involved giving patients immune cells from a donor, along with several drugs, to see if the body could better fight the cancer. The main goal was to find a safe dose and …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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New cancer treatment strategy aims to reduce harsh side effects
Disease control CompletedThis study tested whether a three-part treatment approach could reduce side effects and improve outcomes for people with head and neck cancer. Forty patients received chemotherapy first to shrink tumors, followed by minimally invasive surgery, and then radiation/chemotherapy tail…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Tailored treatment tested for tough head & neck cancers
Disease control CompletedThis study tested a personalized approach for patients with advanced head and neck cancer that had worsened despite prior immunotherapy. Doctors analyzed each patient's tumor to select one of two drug combinations to add to a standard immunotherapy drug. The goal was to see if th…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Dan Zandberg • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Old drug gets new look as last hope for tough head & neck cancers
Disease control CompletedThis study tested whether an older chemotherapy drug called mitomycin C could help control advanced head and neck cancer that had grown despite all standard treatments. It involved 48 adults whose cancer had spread or returned and was no longer responding to common therapies. The…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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Early trial tests new combo for Tough-to-Treat head & neck cancers
Disease control CompletedThis early-stage study tested the safety of combining two immunotherapy drugs, IRX-2 and durvalumab, for patients with incurable head and neck cancer. The main goal was to find the highest dose patients could tolerate without severe side effects and to see if the treatment increa…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Early trial tests new drug mixes to shrink tumors before surgery
Disease control CompletedThis early-phase study tested different combinations of immunotherapy and chemotherapy drugs in patients with advanced head and neck cancer that could be surgically removed. The goal was to see if these treatments given before surgery could shrink or even eliminate the tumor. The…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1, PHASE2 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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Experimental pill tested to boost radiation against head & neck cancer
Disease control CompletedThis early-phase study tested whether adding an experimental pill called afatinib to standard radiation therapy (with or without chemotherapy) was safe for people who had surgery for head and neck cancer. The main goal was to find the highest dose of afatinib that patients could …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Drug trial aims to stop Cancer's return after surgery
Disease control CompletedThis study tested whether adding the immunotherapy drug pembrolizumab (MK-3475) to standard surgery could better control advanced head and neck cancer. It involved 67 high-risk patients with stage III or IV cancer that could be surgically removed. Researchers aimed to see if the …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Radiation 'Priming' tested to supercharge cancer immunotherapy
Disease control CompletedThis study tested if a short, targeted dose of radiation given right before starting standard immunotherapy could improve results for people with advanced lung or head/neck cancer. The idea was that radiation might release cancer markers to help the immune drugs work better. Rese…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: John L. Villano, MD, PhD • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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MRI guides stronger radiation blast to tough cancer spots
Disease control CompletedThis study tested a new way to give radiation therapy to people with advanced head and neck cancer that has a poor outlook. Doctors used a special MRI scan to find parts of the tumor that might resist standard radiation and then gave a higher, focused dose just to those areas. Th…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control
Last updated Mar 16, 2026 15:24 UTC
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Radiation planning battle: which method spares patients from debilitating dry mouth?
Symptom relief CompletedThis study aimed to see if a newer method for planning radiation therapy could reduce a common and distressing side effect—severe dry mouth—for patients with head and neck cancer. It compared two planning techniques in 23 patients to see which one better preserved saliva gland fu…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: NA • Sponsor: University of Arkansas • Aim: Symptom relief
Last updated Mar 16, 2026 15:25 UTC
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Study asks: how do patients feel about their High-Risk skin cancer care?
Knowledge-focused CompletedThis study aimed to better understand the patient experience for people with a high-risk form of skin cancer on the head or neck. Researchers asked 78 patients to complete surveys about their quality of life, how difficult their treatment decisions were, and how satisfied they we…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Sponsor: Maastricht University Medical Center • Aim: Knowledge-focused
Last updated Mar 18, 2026 18:25 UTC