New MRI-Guided radiation aims to spare cancer patients from chronic dry mouth

NCT ID NCT03972072

Completed Symptom relief Sponsor: Panagiotis Balermpas Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This study tests a new type of radiotherapy that uses daily MRI scans to precisely target head and neck cancer while avoiding the saliva glands. The goal is to reduce severe dry mouth, a common and lasting side effect. Forty-nine patients will receive this adaptive treatment and be followed for two years to measure saliva flow and dry mouth severity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MRI-guided adaptive radiotherapy
What this could lead to: If it works, this approach could significantly reduce chronic dry mouth in head and neck cancer survivors, improving their quality of life.
What could go wrong: This is a small, early-phase study with only 49 participants, so results may not apply to everyone. The technique is complex and may not be widely available.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER XEROSTOMIA DUE TO RADIOTHERAPY

Contacts and locations

Locations

Zurich University Hospital

Zurich, 8091, Switzerland

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