New drug combo aims to boost Radiation's punch against head and neck cancer

NCT ID NCT01783587

Completed Disease control Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tested the safety of adding the drug afatinib to standard radiation therapy for people with head and neck cancer at risk of recurrence. Afatinib blocks proteins that help cancer grow and may make cancer cells more sensitive to radiation. The study included 29 participants and aimed to find the safest dose of afatinib when given with radiation, with or without chemotherapy.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

Contacts and locations

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Locations

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Massachusetts General Hospital

Boston, Massachusetts, 02115, United States
Mount Sinai Medical Center/Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States