Dana-farber Cancer Institute

This study tests a personalized vaccine made from unique markers on a person's CLL cells. It is for 15 people with untreated, slow-growing CLL. The vaccine aims to train the immune system to fight the cancer, and may be given alone or with other drugs to boost its effect.

This study tests whether the drug casdatifan, alone or with zimberelimab, can safely shrink kidney tumors before surgery. About 32 adults with clear cell renal cell carcinoma that can be removed will receive the drugs before their operation. The goal is to see if the tumor size d…

This study tests a counseling and education program designed to help Chinese and Korean American smokers quit smoking and get screened for lung cancer. About 50 participants will receive the program and be followed for 6 months. The goal is to see if the program helps people stop…

This early-phase study tests a new drug, SL-401, combined with standard treatments (azacitidine and venetoclax) for people with certain blood cancers like acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and blastic plasmacytoid dendritic cell neoplasm (BPDCN). The g…

This early-phase study tests whether adding pembrolizumab (an immunotherapy) to standard chemotherapy is safe and effective for people newly diagnosed with primary central nervous system lymphoma, a rare brain cancer. About 15 participants will receive the combination and be moni…

This study tests a drug called belumosudil in people who have developed a serious lung condition (bronchiolitis obliterans syndrome) after a stem cell transplant. The goal is to see if the drug can improve lung function or slow the disease. About 45 adults with new or early-stage…

This study tests whether adding the targeted drug T-DM1 to standard chemoradiation can prevent HER2-positive salivary gland cancer from returning after surgery. About 37 adults with advanced but removable tumors will receive the drug alongside standard care. Researchers will trac…

This study is for people with HPV-related throat cancer who have had surgery. It tests whether a lower, personalized dose of radiation (and sometimes chemo) can control the cancer while causing fewer side effects and improving quality of life. About 111 adults will take part.

This early-phase study tests a new treatment called CIML NK cell therapy for people with recurrent ovarian cancer that no longer responds to platinum chemotherapy. The therapy uses specially trained natural killer cells from a donor to attack the cancer. The study aims to find th…

This study tests a drug called pemigatinib in 24 people with a rare, advanced stomach cancer called SDH-deficient GIST that cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease. Researchers will also monitor side effects to unders…

This study tests a program called CHEF that helps childhood cancer survivors and their families cook and eat healthier foods. The goal is to improve diet quality and support long-term heart health. About 17 children who finished cancer treatment will take part for 6 months.

This early-phase study tests whether giving special immune cells (CIML NK cells) after a stem cell transplant can help prevent relapse in people with high-risk blood cancers like acute myeloid leukemia. About 15 participants will receive the cells along with a drug called IL-2. T…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) early can slow the growth of adenoid cystic carcinoma that has spread to a few spots in the body. About 32 people with 1 to 5 metastatic lesions will receive SBRT, and researchers will track how long …

This study tests a pill called abemaciclib in people with advanced solid tumors that have certain gene changes (CCND1, CCND2, CCND3, CDK4, or CDK6). The goal is to see if the drug can stop or slow cancer growth. About 38 adults whose cancer has not responded to standard treatment…

This early-phase study tests the safety of giving special immune cells (CIML NK cells) along with a standard drug (venetoclax) to people with acute myeloid leukemia (AML) that has come back or is hard to treat. About 10 adults will receive the cell infusion after a short chemothe…

This study tests whether combining two targeted drugs, zanubrutinib and venetoclax, can make cancer undetectable in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose disease came back after prior treatment. About 45 adults who have not used …

This study tests a daily pill called elacestrant in 30 people with advanced uterine sarcomas that have high levels of estrogen receptors. The drug works by blocking and breaking down estrogen receptors, aiming to shrink or slow tumor growth. The main goals are to see how many pat…

This study tests whether adding pembrolizumab to sacituzumab govitecan helps control metastatic triple-negative breast cancer that is PD-L1-negative. About 110 adults with advanced TNBC will be randomly assigned to receive either the combination or sacituzumab alone. The goal is …

This study tests whether adding AGuIX nanoparticles to precise, MRI-guided radiation can better control centrally located lung tumors and advanced pancreatic cancer. About 100 adults with these cancers will receive the combination therapy. The goal is to find the safest dose and …

This early-stage trial tests a special type of immune cell (CIML NK cells) combined with a low dose of IL-2 in people whose blood cancer (like AML or MDS) came back after a stem cell transplant. The goal is to find a safe dose and see if it can put the cancer back into remission.…

This study tests whether a 16-week, culturally tailored exercise program (aerobic and resistance training) can lower heart disease risk in Black men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). About 62 participants will be randomly assig…

This study tests a drug called belzutifan in people with a rare, hard-to-treat type of gynecologic cancer called clear cell carcinoma. The goal is to see if the drug can shrink tumors or stop them from growing. About 32 participants will receive the drug, and researchers will mon…

This study tests whether two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from getting worse. About 32 people with a specific type of estrogen-sensitive cancer will take these pills daily after initial treatment. The goal is to see if t…

This study is for people with metastatic urothelial carcinoma, a type of bladder cancer that has spread. It tests combinations of three drugs: sacituzumab govitecan, enfortumab vedotin, and pembrolizumab. The goal is to find safe doses and see how well they shrink tumors. About 1…

This phase 2 trial tests two drugs, ficerafusp alfa and pembrolizumab, given before surgery to people with advanced head and neck cancer that can be removed. The goal is to see if the combination can shrink tumors and improve outcomes. About 32 participants will receive the treat…

This study is testing a new blood test that looks for DNA from lung cancer cells in people who are at risk but cannot get regular lung cancer scans. It includes 1,000 healthy Asian and Latinx adults who do not currently smoke. The goal is to see how well the test finds early-stag…

This study is testing a blood test called the GRAIL Galleri test to see if it can detect many types of cancer early in people who have a high genetic risk for cancer. About 1,000 adults with certain inherited cancer syndromes or gene changes will take the test. The goal is to fin…

This study is testing whether adding simple blood tests and symptom reviews to standard screening can find pancreatic cancer earlier in people with a high genetic risk. About 5,000 participants with certain gene changes will be followed over time. The goal is to catch cancer at a…

This study tests a light therapy device (like a lollipop with LEDs) to prevent severe mouth sores in 20 adults receiving a stem cell transplant. Patients use the device daily in the hospital. The goal is to see if it reduces the number of days with painful sores.

This study looks at whether home-based exercise and nutrition programs can improve memory, thinking, and physical abilities in older adults (65+) who have finished cancer treatment. About 1,500 cancer survivors and their support partners will either follow a program with virtual …

This study looks at whether a telehealth exercise program with protein support can help women aged 65 and older with breast cancer receive all their planned chemotherapy at the right dose. Participants will either do resistance exercises and take protein or receive health educati…

This study is testing a program called UPLYFT for lymphoma survivors who worry a lot about their cancer returning. The program provides information and tools to improve quality of life and reduce those worries. About 74 survivors who finished treatment 3 to 24 months ago and are …

This study tests whether a 12-week program that breaks up long periods of sitting can help people with lymphoma who are starting chemotherapy. Researchers want to see if it's doable and if it improves heart health and reduces side effects. About 24 newly diagnosed adults will tak…

This study looks at whether a 12-week online dance program can improve quality of life, reduce pain, and ease fatigue in breast cancer survivors who have ongoing pain after surgery. About 30 adults who had a lumpectomy or mastectomy and still have moderate to severe pain will tak…

This study tests whether a special cooling cap can reduce hair loss in people with metastatic breast cancer who are receiving certain chemotherapy drugs. About 120 participants will either use the Paxman Scalp Cooling System or not, and researchers will compare hair loss rates an…

This study looks at two treatment options for people aged 65 and older with advanced bladder cancer who cannot take the chemotherapy drug cisplatin. The goal is to see which treatment better maintains quality of life and causes fewer side effects. Participants will receive either…

This study tests a mobile app program called PRISM to help teens and young adults (ages 12-25) who have finished cancer treatment manage stress and build resilience. Participants will use the app to learn skills to cope with difficult situations. The goal is to see which version …

This study tests whether a 12-week online tai chi program is practical and helpful for cancer survivors who have nerve damage and balance problems from chemotherapy. About 21 adults who finished chemo at least 3 months ago will take part. The goal is to see if tai chi can ease sy…

This study looks at whether adding a special support program (called RISE) to usual care can reduce financial and material hardships for low-income families of children with high-risk neuroblastoma. About 84 children and their parents will take part, with half getting the extra s…

This study looks at whether a 12-week exercise program can help people with advanced lung cancer who are already receiving immunotherapy. Researchers will test different exercise intensities to see if they are safe and can improve immune markers. The study involves 30 adults with…

This study looks at whether a home-based resistance exercise program plus daily protein supplements can help people with pancreatic cancer maintain muscle mass while on chemotherapy. About 45 participants will be split into three groups: exercise with protein, exercise only, or g…

This study tests whether a 16-week virtual exercise program (aerobic and resistance training) can help patients with ovarian or endometrial cancer maintain leg function and reduce numbness or tingling in hands and feet caused by chemotherapy. About 30 adults who have had surgery …

This study explores whether regular video or phone check-ins between hospice patients with advanced breast cancer and their oncology team can improve the hospice experience. About 200 participants, along with their caregivers and nurses, will take part. The goal is to see if this…

This study tests a telehealth program called REVITALIZE to see if it can reduce how much fatigue interferes with daily life for adults with advanced ovarian cancer who are taking PARP inhibitors. About 240 participants will either receive the REVITALIZE program or educational mat…

This study looks at whether offering blood transfusions at home for people with advanced blood cancers who are in hospice care can improve their quality of life, mood, and reduce hospital visits near the end of life. About 700 adults with relapsed or hard-to-treat blood cancers w…

This study tests a program called BOLSTER designed to support people with advanced gynecologic or gastrointestinal cancers and their caregivers. The program helps with complex care needs like managing ostomies or feeding tubes. Researchers will measure changes in quality of life …

This study is testing an online educational program called On-Trac to help adult cancer survivors cope with anxiety. The program teaches practical strategies based on well-known therapies like CBT and ACT. Researchers will measure changes in anxiety levels and emotional well-bein…

This study tests whether an 8-week home exercise program, done before a stem cell transplant, can improve muscle strength and physical fitness in people with multiple myeloma. Thirty participants will either exercise or continue normal activities. The goal is to see if pre-transp…

This study tests a tool called CASI that helps ovarian cancer patients, their caregivers, and doctors set a shared plan for each visit. The goal is to see if using this tool is practical and helpful. About 112 people with advanced ovarian cancer and their caregivers will take par…

This study looks at whether a home-based aerobic and resistance exercise program is feasible for adults with graft-versus-host disease (GVHD) after a stem cell transplant. Participants will either do aerobic and resistance exercises or simple stretching. The goal is to see if exe…

This study tests whether a 16-week virtual high-intensity interval training (HIIT) program can improve physical fitness, thinking skills, and emotional well-being in young adults (ages 18-45) who survived a childhood brain tumor. Participants exercise from home with guidance, and…

This study tests whether a 16-week supervised exercise program (combining strength, functional, and aerobic exercises) can improve frailty and muscle loss in 80 men with metastatic prostate cancer who are on hormone therapy. Participants must be pre-frail or frail. The goal is to…

This study tests whether a device that cools and squeezes the arms and legs during chemotherapy can help prevent or reduce nerve damage, which often causes numbness, tingling, and pain. About 50 adults with breast or gynecologic cancer receiving a specific type of chemo (taxanes)…

This study looks at genetic changes in people with early-stage blood cancers or conditions that may lead to cancer. Researchers will analyze blood, bone marrow, or cheek cell samples from up to 10,000 participants to find DNA errors linked to cancer risk and progression. The goal…

This study is testing a web-based tool called TRIAL that gives people with acute leukemia easy-to-understand information about their disease and how to join clinical trials. Researchers want to see if the tool is easy to use and helpful for patients. About 75 English-speaking adu…

This study collects tissue samples and medical information from up to 2750 people with chronic lymphocytic leukemia (CLL) or related conditions. Researchers hope to learn more about what causes CLL and how it behaves. Participants provide samples during routine care, with no extr…

This study looks at whether special imaging and dye can help doctors find the first lymph nodes that cancer might spread to in people with inflammatory breast cancer. About 50 women with this rare and aggressive cancer will take part. The goal is to see if these methods work well…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives patients and their doctors updated information about gene changes that may increase cancer risk. Researchers want to see if the too…

This study aims to make clinical trials more inclusive by training 40 adults who are in remission from blood cancer to review and give feedback on trial plans. The goal is to see if this community-based review process is practical and acceptable. The study does not test a new tre…

This study is collecting tissue samples from 240 adults with malignant pleural mesothelioma to test a new method that combines molecular, radiological, and blood tests. The goal is to create a score that helps doctors better predict how the disease will progress. Participants mus…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to cancer treatment can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online …

This study aims to uncover genetic factors that increase the risk of thyroid cancer, especially in children and families with a strong history of the disease. Researchers will collect medical history and blood or saliva samples from 250 participants. The goal is to identify inher…

This study collects tumor samples and medical information from people with lymphoma or related blood cancers who have a family history of these diseases. Researchers want to find genetic changes that may increase the risk of developing lymphoma. Participants provide blood or tiss…

This study follows 30,000 people who have early signs that may lead to multiple myeloma, a type of blood cancer. Participants have conditions like MGUS or smoldering myeloma, or have a family history of blood cancers. Researchers will track them over time to learn what factors in…

This study looks at how vitamin D affects colon cancer cells. Researchers want to see if high doses of vitamin D can change how cancer cells grow. About 80 people with stage I-III colon cancer or colon cancer that has spread to the liver will take vitamin D before their surgery. …

This study looks at whether a pre-surgery program of exercise and nutrition advice is practical for people with stage II or III rectal cancer. About 40 participants will either join the program or receive usual care. The main goal is to see if enough people sign up and stick with…

This study looks at whether a video education program helps people with certain cancers (like breast, ovarian, or prostate cancer) better understand genetic testing and their hereditary cancer risk. About 1,020 participants will watch videos and answer questions. The goal is to m…

This study looks at whether families of children with cancer are willing to take part in a program called PediRISE, which provides financial support. About 40 families will be randomly assigned to either receive the support or standard care. The goal is to see if the program is f…

This study aims to learn more about lung cancer in adults diagnosed at age 45 or younger. Researchers will collect blood samples and medical information from 500 participants to study the biology of these cancers and look for genetic changes that could lead to better treatments. …

This study is collecting information and samples from 1,500 people with TP53 gene changes (linked to Li-Fraumeni Syndrome, a condition that raises cancer risk) and their relatives. Researchers want to better understand how these gene variants affect cancer risk and how accurate f…

This study is for people with a type of skin cancer called cutaneous squamous cell carcinoma who are waiting for surgery to remove their tumor. Researchers want to see if injecting the seasonal flu vaccine directly into the tumor can boost the immune system's ability to attack th…

This study tests a shared decision-making toolkit for women aged 80 and older who have had breast cancer. The goal is to help them and their doctors decide together whether to continue yearly mammograms. About 364 participants will use the toolkit, and researchers will track how …