Dana-farber Cancer Institute

This study tests whether giving two targeted drugs (T-DM1 and pertuzumab) before surgery can eliminate all signs of cancer in women with early-stage HER2-positive breast cancer. About 164 participants with stage II or III disease will receive the combination, and doctors will che…

This early-phase trial tests a new three-drug combination (ribociclib, everolimus, and dexamethasone) in children and young adults up to age 30 whose acute lymphoblastic leukemia has returned or not responded to standard treatments. The main goals are to find the safest dose and …

This study tests whether adding the targeted drug ibrutinib to standard chemotherapy (FCR) can eliminate all traces of leukemia in younger, previously untreated patients with chronic lymphocytic leukemia (CLL). About 85 participants will receive the combination and then be monito…

This study tests whether a 16-week home-based, virtually supervised high-intensity interval training (HIIT) program can slow prostate cancer progression in Black men who are on active surveillance (monitoring the cancer without immediate treatment). The trial enrolls 68 Black men…

This study is for children and teens newly diagnosed with acute lymphoblastic leukemia (ALL), a cancer of the blood. The standard treatment is about 2 years of chemotherapy. This trial tests a new set of risk factors to decide how strong the treatment should be, and a new way to …

This study tests two drugs, ipilimumab and nivolumab, given alone or together to adults with classic Hodgkin lymphoma that has returned or not responded to prior therapy. The goal is to shrink or control the cancer. The trial enrolled 13 participants and is no longer recruiting n…

This early-phase study tests a new treatment for people whose blood cancer (like AML or MDS) has returned after a donor stem cell transplant. The treatment combines a special type of donor immune cell infusion with an immunotherapy drug (ipilimumab) to help fight the cancer. The …

This study compares a new form of chemotherapy (calaspargase pegol) given every 3 weeks to the standard form (Oncaspar) given every 2 weeks in children and teens with acute lymphoblastic leukemia or lymphoblastic lymphoma. The goal is to see if the new drug has similar side effec…

This study is testing whether combining two drugs, copanlisib and venetoclax, can help people with a type of blood cancer called diffuse large B-cell lymphoma that has come back or not responded to prior treatments. About 48 adults will take part. The goal is to find the safest d…

This early-phase study tests a modified herpes virus designed to attack brain tumor cells directly. The virus is injected into the tumor, and some participants also receive a drug to boost the immune response. The main goal is to find the safest dose and see how the body reacts. …

This study tests a new drug (duvelisib) combined with an approved drug (venetoclax) in 55 adults whose chronic lymphocytic leukemia (CLL) or Richter's syndrome has come back or not responded to prior treatment. The goal is to see how well the combination shrinks or controls the c…

This study tests a treatment called cilta-cel, which uses a patient's own immune cells (T cells) that are modified to attack myeloma cells. It is for people with high-risk smoldering myeloma, a condition that often leads to active multiple myeloma. The goal is to see if this one-…

This study tested a two-step drug combination (rituximab/bendamustine followed by rituximab/cytarabine) in 23 adults with newly diagnosed mantle cell lymphoma who were eligible for a stem cell transplant. The goal was to see if this approach could improve the number of patients a…

This study tested a combination of two drugs, ibrutinib and obinutuzumab, in 54 adults with chronic lymphocytic leukemia (CLL) that had come back or stopped responding to treatment. The main goal was to check safety and find the best doses. Researchers also looked at how well the…

This early-phase study tests a personalized vaccine (NeoVax) made from a patient's own tumor mutations, given alongside a drug that boosts immune cells (CDX-301) and either nivolumab or pembrolizumab (immunotherapies). The goal is to find the safest dose and see if the combinatio…

This study tests a drug called daratumumab in people with two early blood conditions that can lead to multiple myeloma. The goal is to see if the drug can reduce or control the abnormal cells, preventing progression to active cancer. Participants receive treatment for up to 20 cy…

This study looks at women with HER2-positive breast cancer who had a complete response to a three-drug combination before surgery. The goal is to see if they can safely skip chemotherapy after surgery and only receive two antibody drugs. About 100 participants are enrolled to tes…

This study tests a combination of two drugs, olaparib and sapacitabine, in people with advanced breast cancer that has a BRCA gene mutation. The main goals are to find the safest dose and see if the drugs shrink tumors. About 10 participants are enrolled in this early-phase trial…

This study tests whether metformin, a widely used diabetes medicine, can prevent the progression of two precancerous blood conditions (MGUS and smoldering multiple myeloma) into active multiple myeloma. About 60 participants will receive either metformin or a placebo pill for a p…

This study tests two brief video-based programs to help young women (ages 19-49) who have had cancer and are dealing with sexual health issues. About 84 participants will join from home via videoconference. The goal is to see which program better improves sexual function and redu…

This study is testing whether people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) can safely increase their dose of venetoclax faster than the usual 5-week schedule. The main goal is to see which risk groups for tumor lysis syndrome can tolerate a d…

This study looks at whether a 16-week home exercise program can help Black and Hispanic patients with breast, colorectal, or prostate cancer become more active during chemotherapy. Participants are assigned to supervised exercise via Zoom, unsupervised exercise, or stretching. Th…

This study looks for inherited gene changes (EGFR mutations) that may increase the risk of lung cancer, especially in people who never smoked. Researchers collect saliva from cancer patients with a specific tumor mutation (T790M) to see if they carry an inherited mutation. Close …

This study looks at whether a genomic test called Prosigna can help doctors and patients choose the best treatment before breast cancer surgery. It involves 60 women with a specific type of breast cancer (HR+/Her2-). The main goal is to see if the test results change the treatmen…

This early-phase trial is testing the immunotherapy drug pembrolizumab in 60 adults whose glioblastoma (a type of brain cancer) has come back or worsened. The main goal is to see how the drug affects immune cells inside the tumor and to check for side effects. Participants receiv…

This study looks at how a 12-week physical activity program affects certain markers in the breast tissue and blood of premenopausal women with dense breasts. Dense breast tissue is a risk factor for breast cancer, and the goal is to see if exercise can cause changes that might lo…

This study follows 253 breast cancer patients aged 70 and older to learn how to improve their treatment and health outcomes. Researchers will track what treatments doctors recommend, how well patients stick to hormone therapy, and what barriers they face. The goal is to find bett…

This study looks at whether whole body MRI scans can help find cancer early in children and adults with Li-Fraumeni syndrome, a genetic condition that greatly increases cancer risk. About 150 participants will get annual scans for four years to see if they keep coming back and ho…

This study follows over 1,300 women aged 40 or younger who were recently diagnosed with breast cancer. Researchers collect surveys, blood samples, and tumor tissue to learn about short- and long-term effects of the disease and its treatment, including fertility, sexual health, an…

This study looks at how people feel physically and emotionally after having a breast biopsy for certain non-cancerous but unusual breast conditions. Researchers are surveying over 900 patients from several hospitals to understand pain and quality of life years after the procedure…