New drug combo offers hope for advanced breast cancer patients

NCT ID NCT03147287

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 24 times

Summary

This study tests three drug combinations for people with a common type of advanced breast cancer (ER+/HER2-) that has stopped responding to initial hormone therapy. About 220 participants will receive either fulvestrant alone, fulvestrant plus palbociclib, or fulvestrant plus palbociclib and avelumab. The goal is to see which combination works best to delay cancer growth.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Aurora Cancer Care

    Milwaukee, Wisconsin, 53215, United States

  • Baylor University

    Houston, Texas, 77030, United States

  • Boston Medical Center

    Boston, Massachusetts, 02188, United States

  • DF/BWCC at Milford Regional Medical Center

    Milford, Massachusetts, 01757, United States

  • DF/BWCC in clinical affiliation with South Shore Hospital

    South Weymouth, Massachusetts, 02190, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dana-Farber at St. Elizabeth's Medical Center

    Brighton, Massachusetts, 02135, United States

  • Dana-Farber/New Hampshire Oncology-Hematology

    Londonderry, New Hampshire, 03053, United States

  • Eastern Maine Medical Center

    Bangor, Maine, 04401, United States

  • Emory University - Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • The University of Kansas Cancer Center

    Westwood, Kansas, 66205, United States

  • The University of Kansas Cancer Center - Lee's Summit

    Lee's Summit, Missouri, 64064, United States

  • The University of Kansas Cancer Center - North

    Kansas City, Kansas, 64154, United States

  • The University of Kansas Cancer Center - Overland Park

    Overland Park, Kansas, 66210, United States

  • University of Louisville

    Louisville, Kentucky, 40202, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Washington University

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.