Dana-farber Cancer Institute

This study tests an experimental drug called FHD-286 in people with a specific type of small-cell lung cancer that has a marker called POU2F3. Participants must have already tried at least one standard chemotherapy. The drug is taken daily in 3-week cycles. The main goal is to se…

This study is for adolescents and young adults (ages not specified) with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL). Researchers want to see if a specific combination of chemotherapy drugs plus the immunotherapy blinatumomab helps more pat…

This phase 3 study tests a personalized treatment approach for people with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. The treatment plan uses a combination of drugs (isatuximab, iberdomide, bortezomib, and dexamethasone) and is adjusted based on…

This study tests a program to help women with ER-positive breast cancer in Rwanda take their daily hormone therapy as prescribed. The program includes education, reminders, and behavioral support. Researchers will measure how well participants stick with their medication and how …

This study tests a combination of four drugs (isatuximab, iberdomide, bortezomib, and dexamethasone) in people newly diagnosed with multiple myeloma who cannot or choose not to have a stem cell transplant. The goal is to find the safest and most effective dose to control the dise…

This study tests whether a blood test that tracks HPV DNA can help doctors choose the right amount of treatment for people with HPV-positive throat cancer. About 116 participants with early-stage cancer will receive therapy tailored to their risk level, aiming to improve survival…

This study tests a drug called cosibelimab in people with advanced skin cancer who also have a kidney transplant or a blood cancer. The goal is to see if the drug is safe and helps shrink tumors. About 80 adults will take part.

This study will check if a blood test called the GRAIL Galleri test can find many types of cancer in people who already have symptoms. About 100 adults will take the test, and researchers will compare the results to standard methods. The goal is to see how accurate the test is an…

This study compares two low-dose hormone therapies, exemestane and tamoxifen, in 140 postmenopausal women at high risk for breast cancer. The goal is to see which drug causes fewer menopausal side effects while still helping to prevent breast cancer. Participants will take the me…

This study tests whether adding acupuncture to virtual exercise can help manage nerve pain caused by a specific bladder cancer treatment (EV-Pembro). About 50 adults with advanced bladder cancer will be split into two groups: one gets acupuncture plus virtual exercise, the other …

This study is testing a smartphone app called I-STAMP that helps people with advanced cancer keep track of their pain and medications. About 73 participants will use the app and rate how easy it is to use and how helpful it is. The goal is to see if the app can make managing canc…

This study tests a new educational program called SHARE-MC for women with metastatic breast cancer who are bothered by sexual problems. The program aims to improve sexual function and reduce emotional distress. About 96 women will take part online. The goal is to see if this prog…

This study is testing a new web and mobile app called SHIELD designed to help women with hormone-positive breast cancer who are on long-term endocrine therapy. The goal is to see if it's possible to enroll 30 women and have them use the app. This is a pilot study, so it's mainly …

This pilot study tests whether a personalized exercise program is practical for people with stage II or III lung cancer. About 20 participants will follow the program before and after their cancer treatment. The main goal is to see if they can attend at least 80% of the exercise …

This study is testing a mobile app called my.naviGATE for teens and young adults (ages 15-24) who have finished cancer treatment. The app provides personalized education, peer support, and tracks how patients are doing. Researchers want to see if it helps patients feel more confi…

This study is building an AI tool called ACTIVATE that scans electronic health records to find cancer patients who may be eligible for clinical trials. Researchers will test whether sending alerts to doctors increases the number of patients starting trials. The goal is to make it…

This study aims to create a nutrition algorithm called NACHO to help cancer patients improve their nutritional status and quality of life during or after treatment. Researchers will gather data from 130 participants, including patients, dietitians, and advisors, to build and test…