Dana-farber Cancer Institute

This study tests whether giving two drugs—ficerafusp alfa and pembrolizumab—before surgery can shrink tumors in people with advanced head and neck cancer. About 32 participants with resectable, PD-L1-positive tumors will receive the combination, then have surgery. The main goal i…

This early-phase trial tests a new treatment for people whose leukemia or related blood cancers return after a stem cell transplant. The therapy uses specially trained natural killer (NK) cells from a donor, followed by low-dose IL-2 to help them work. The main goal is to find th…

This early-phase study tests whether a new immune cell therapy, called memory-like natural killer (NK) cells, can be safely given to people with advanced kidney or bladder cancers. The NK cells are taken from the patient's blood, treated with special proteins to boost their cance…

This study tests whether the drug belzutifan can shrink or slow the growth of clear cell cancers of the ovary, uterus, cervix, vagina, or vulva that have come back or not gone away. About 32 adults with these rare cancers will receive belzutifan pills. The goal is to see how many…

This early-phase study tests a drug called SL-401 combined with other medicines (azacitidine and venetoclax) in people with certain blood cancers (AML, MDS, or BPDCN) that have come back or are hard to treat. The main goal is to find the safest dose and see if the combination hel…

This study tests a program called CHEF that helps childhood cancer survivors and their families cook and eat healthy foods. The goal is to support heart health after cancer treatment. The study will enroll 17 children who have finished or are finishing chemotherapy or radiation t…

This study tests a drug called belumosudil in people who have developed a serious lung condition (bronchiolitis obliterans syndrome) after a stem cell transplant. The goal is to see if the drug can improve or stabilize lung function. About 45 participants will receive the drug al…

This early-stage study tests a new treatment called CIML NK cell therapy for people with recurrent ovarian cancer that no longer responds to platinum chemotherapy. The therapy uses specially trained natural killer cells from a donor to attack the cancer. The study aims to find th…

This early-phase trial tests whether giving special immune cells (CIML NK cells) along with a drug called IL-2 after a stem cell transplant can safely prevent leukemia or related blood cancers from coming back. The study includes 15 adults with high-risk acute myeloid leukemia, m…

This study tests a combination of three drugs (pembrolizumab, ibrutinib, and rituximab) in about 37 people whose primary central nervous system lymphoma has come back or not responded to prior treatment. The goal is to see if the combo can stop the cancer from growing for at leas…

This study tests whether giving focused radiation (SBRT) early can slow the spread of adenoid cystic carcinoma that has already spread to a few spots in the body. Researchers will track how long the cancer stays controlled, side effects, and quality of life. The trial enrolls 32 …

This study is testing a new blood test that looks for DNA from lung cancer cells. It is for healthy Asian and Latinx people aged 50-80 who do not smoke but cannot get regular lung cancer screening. The goal is to see if the test can find lung cancer early so treatment can start s…

This study looks at whether exercise can help lower the risk of breast cancer in women with dense breast tissue. Researchers will measure changes in blood and breast tissue in 46 women who are not very active. Half will start a supervised exercise program, while the other half wi…

This study tests whether a special cooling cap (Paxman Scalp Cooling System) can reduce hair loss in people with metastatic breast cancer who are receiving certain chemotherapy drugs. About 120 participants will be randomly assigned to use the cooling cap or not. The goal is to s…

This study tests a 6-session therapy program called Acceptance & Commitment Therapy (ACT) for cancer patients who are at risk of misusing opioids. The goal is to see if the program is practical and helpful for managing psychological symptoms like difficult thoughts and emotions. …

This study looks at whether a 16-week supervised exercise program (combining strength training and aerobic exercise) can improve frailty and muscle loss in men with metastatic prostate cancer who are on hormone therapy. The study will enroll 80 men who are already frail or pre-fr…

This study tests whether a 16-week high-intensity interval training (HIIT) program can help women with breast cancer keep their thinking skills sharp during chemotherapy. Thirty women newly diagnosed with stage I-III breast cancer will participate. The goal is to see if exercise …

This study tests whether a 16-week virtual high-intensity interval training (HIIT) program can improve physical fitness, thinking skills, and emotional well-being in young adults (ages 18-45) who survived a childhood brain tumor. Participants exercise from home using video guidan…

This study tests a program called UPLYFT for lymphoma survivors who worry about their cancer returning. About 74 survivors who finished treatment 3 to 24 months ago will take part. The program provides information and tools to improve quality of life and reduce cancer-related wor…

This study looks at whether a 12-week exercise program can help people with advanced lung cancer who are receiving immunotherapy. Researchers will test different exercise intensities to see if they are safe and helpful. The goal is to improve treatment outcomes and quality of lif…

This study tests a program called BOLSTER designed to help patients with advanced gynecologic or gastrointestinal cancers and their caregivers. The program provides extra support for those with new or complex care needs, such as managing a feeding tube or ostomy. Researchers will…

This study tests whether an 8-week home exercise program, done before a stem cell transplant, can improve muscle strength and physical fitness in people with multiple myeloma. Participants will either exercise with virtual coaching or continue their normal routine. The goal is to…

This study collects tissue samples from 240 adults with malignant pleural mesothelioma to test a new method that combines molecular, radiological, and blood tests to predict how the disease will progress. The goal is to help doctors better determine each patient's prognosis and t…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives patients and their doctors access to updated information about genetic findings, including uncertain results. The goal is to see if…

This study is collecting information and samples from 1,500 people with TP53 gene changes (linked to Li-Fraumeni Syndrome, a condition that raises cancer risk) and their relatives. The goal is to better understand how these gene variants affect cancer risk and family history. No …