Supercharged immune cells aim to stop leukemia relapse
NCT ID NCT06138587
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether specially trained natural killer (NK) cells, called CIML NK cells, along with interleukin-2 (IL-2), can safely prevent leukemia from coming back after a stem cell transplant. The study enrolls 15 adults with high-risk acute myeloid leukemia, myelodysplastic syndrome, or related blood cancers who still have signs of disease before transplant. Participants receive one infusion of donor-derived CIML NK cells plus IL-2 shots, and researchers monitor for side effects and the best dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cytokine-induced memory-like natural killer (CIML NK) cells and interleukin-2 (IL-2)
- What this could lead to
- If successful, this approach could help prevent leukemia relapse after a stem cell transplant, improving long-term survival for high-risk patients.
- What could go wrong
- This is a very early phase 1 trial with only 15 participants, focused on safety and dosing. It may not show a clear benefit, and there are risks of serious side effects from the cell infusion and IL-2.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Brigham and Women's Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
-
Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
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