Massive study aims to unlock secrets of early blood cancers

NCT ID NCT02269592

Recruiting now Knowledge-focused Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at genetic changes in people with early-stage blood cancers or conditions that may lead to cancer. Researchers will analyze blood, bone marrow, or cheek cell samples from up to 10,000 participants to find DNA errors linked to cancer risk and progression. The goal is to better understand why these cancers develop and how to improve treatment and prevention.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia B-cell chronic lymphocytic leukemia hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm indolent B-cell non-Hodgkin lymphoma leukemia, chronic lymphocytic, susceptibility to, 2 monoclonal gammopathy of uncertain significance myelodysplastic syndrome Myelodysplastic Syndromes premalignant hematological system disease Smoldering Multiple Myeloma smoldering plasma cell myeloma Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-CELL MALIGNANCY, LOW-GRADE HEMATOLOGICAL MALIGNANCIES IGG MONOCLONAL GAMMOPATHY OF UNCERTAIN SIGNIFICANCE MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS) MYELODYSPLASTIC SYNDROME WITH LOW-GRADE LESIONS MYELODYSPLASTIC SYNDROMES SMOLDERING MULTIPLE MYELOMA WALDENSTROM MACROGLOBULINEMIA

Contacts and locations

Locations

Dana Farber Cancer Institute at Merrimack Valley
RECRUITING

Methuen, Massachusetts, 01844, United States
Dana Farber Cancer Institute at Milford Regional Medical Center
RECRUITING

Milford, Massachusetts, 01757, United States
Dana Farber Cancer Institute at South Shore
RECRUITING

Weymouth, Massachusetts, 02190, United States
Dana Farber Cancer Institute at St. Elizabeth's
RECRUITING

Brighton, Massachusetts, 02135, United States
Dana Farber/New Hampshire Oncology-Hematology
RECRUITING

Londonderry, New Hampshire, 03053, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
West Michigan Cancer Center
RECRUITING

Kalamazoo, Michigan, 49007, United States

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