New hope for lung scarring after transplant: belumosudil trial launches
NCT ID NCT05922761
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether the drug belumosudil can help people who develop bronchiolitis obliterans syndrome (BOS), a type of lung scarring, after a stem cell transplant. The study will enroll 45 participants with new or early-stage BOS. Participants will take belumosudil along with standard treatments like steroids and antibiotics to see if lung function improves or stabilizes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Belumosudil (also known as Rezurock), taken as a tablet
- What this could lead to
- If it works, this could offer a new treatment option for lung damage after stem cell transplant, potentially slowing or improving the condition.
- What could go wrong
- This is an early-phase, small trial (45 people) with no placebo group, so results may not be definitive. The drug may not work or could have side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Boston Children's Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
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Brigham and Women's Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
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Stanford University School of Medicine
RECRUITINGStanford, California, 94305, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Cutting radiation in CT scans: a new test of Ultra-Low-Dose imaging
- Can airway cell clues predict a rare lung disease in children?
- Can meditation tame the Long-Term side effects of a stem cell transplant?
- Could a liquid form of a Graft-Versus-Host disease drug be as effective as the pill?
- Can an immunotherapy cocktail shrink inoperable lung tumors?
- Scientists map immune battlefield in chronic GVHD tissue