Can an immunotherapy cocktail shrink inoperable lung tumors?
NCT ID NCT04776447
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This phase II trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation can help people with stage III non-small cell lung cancer that cannot be surgically removed. About 50 participants will receive the combination treatment, and researchers will track how many remain progression-free after one year. The goal is to see if this approach can delay or prevent the cancer from growing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an immunotherapy drug called atezolizumab combined with chemotherapy (carboplatin and paclitaxel) and radiation therapy
- What this could lead to
- If successful, this combination approach could offer a new treatment option for people with advanced lung cancer that cannot be removed by surgery.
- What could go wrong
- This is a small, early-phase trial, so results may not apply to all patients. Side effects from the drug combination, including immune-related reactions, are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hospital Clínico San Carlos
Madrid, Madrid, 28040, Spain
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Hospital Clínico Universitario de Valladolid
Valladolid, Valladolid, 47003, Spain
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Hospital Clínico de Valencia
Valencia, Valencia, 46010, Spain
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Hospital General Universitario de Alicante
Alicante, Alicante, 03010, Spain
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Hospital General Universitario de Elche
Elche, Alicante, 03203, Spain
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Hospital General Universitario de Valencia
Valencia, Valencia, 46014, Spain
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Hospital Parc Taulí
Barcelona, Barcelona, 08208, Spain
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Hospital Santa María Nai
Ourense, Ourense, 32005, Spain
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Hospital Son Espases
Palma de Mallorca, Palma de Mallorca, 07120, Spain
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Hospital Universitario Fundación Jiménez Díaz
Madrid, Madrid, 28040, Spain
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Hospital Universitario HM Sanchinarro
Madrid, Madrid, 28050, Spain
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Hospital Universitario Infanta Leonor
Madrid, Madrid, 28031, Spain
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Hospital Universitario Insular de Gran canaria
Las Palmas de Gran Canaria, Gran Canaria, 35016, Spain
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Hospital Universitario Lucus Augusti
Lugo, Lugo, 27003, Spain
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Hospital Universitario Puerta de Hierro
Majadahonda, Madrid, 28222, Spain
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Hospital Universitario Severo Ochoa
Leganés, Madrid, 28911, Spain
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Hospital Universitario de Jaén
Jaén, Jaén, 23007, Spain
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Hospital de Basurto
Bilbao, Bilbao, 48013, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, 08041, Spain
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Hospitalario Universitario A Coruña
A Coruña, La Coruña, 15006, Spain
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ICO Badalona, Hospital Germans Trias i Pujol
Badalona, Barcelona, 08916, Spain
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ICO Girona, Hospital Josep Trueta
Girona, Girona, 17007, Spain
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